Two arm parallel group randomized trial with double blinding.Simple randomisation using a randomisation table created by computer software with allocation using concealed envelopes. A sample size of 100 with 50 in the control group and 50 in the study/intervention group at a tertiary care hospital.

100

Intervention group having 50 randomly allocated subjects: After tumor resection and neck dissection (supraomohyoid) A total of 20 ml of Tranexamic Acid (TXA) topical solution will be prepared at a concentration of 25 mg/ml by adding one ampule (5 ml) of TXA (100 mg/ml) to 15 ml of normal saline. After achieving complete hemostasis, following supraomohyoid neck dissection for oral, head and neck cancers, 20 ml of TXA solution will be sprayed on the operated field in the neck, once.Dose: 20 ml of topical tranexamic acid at a dose of 25mg/ml (5ml ampule of tranexamic acid containing 100mg/ml of tranexamic acid, mixed with 15ml of normal saline).Mode: Topical (spray solution) Duration: Once before neck closure.There shall be NO repeated administration.Neck Drain Output shall be monitored hourly and once it is less than 25 ml in 24 hrs, drain shall be removed.After spraying the above-mentioned solution, closed suction drain shall be placed and neck closure shall be done in standard way by suturing it in 2 layers.

Control group: 50 randomly allocated subjects, they will NOT receive topical application of tranexamic acid, instead, after tumor resection and neck dissection, and after achieving hemostasis, neck shall be closed in 2 layers (subcutaneous and cutaneous sutures) after placing vacuum suction neck drain.