بررسی تاثیر عصاره هیدروالکلی گیاهان دارویی کتان و سیاهدانه بر روی خستگی بیماران موتیپل اسکلروزیس (MS)

Determining the effect of hydroalcoholic extracts of Flaxseed and Nigella Sativa plants on fatigue in MS patients

A double-blind randomized clinical trial with two groups: Flaxseed, Nigella Sativa, and placebo

The study will be conducted at Imam Reza Hospital. Patients will be randomly divided into two groups of Flaxseed, Nigella Sativa, and placebo by block method. The study is a double-blind (researchers and participants will not be aware of the groups involved).

The Flaxseed and Nigella Sativa group will receive a soft gel containing 0.75 ml of each plant every 12 hours for three months. The control group will receive a 1.5 ml soft gel containing additives.

The English names of plants are written incorrectly.

اسم انگلیسی گیاه کتان و سیاهدانه اشتباه نوشته شده است.

The effect of Flaxseed and Nigella Sativa on MS

The effect of hydroalcoholic extracts of Flaxseed (seed of Linum usitatissimum) and Nigella Sativa plants on fatigue in MS patients

Samples will be randomly assigned to six blocks using Random Allocation Software. Blocking and allocation sequences for concealment will be done by the non-involved researcher (Allocation Concealment). The sample allocation ratio will be Allocation 1:1 and will be divided into two groups of receiving Flaxseed and Nigella Sativa, and Placebo. Then based on blocks and allocation sequences, each client will be given white pockets that are prepared in equal sizes and on which the numbers 1 to 50 are written (in order of allocation sequence). The pockets will contain white boxes containing Flaxseed, Nigella Sativa, or Placebo soft gels. Only the person in charge of packing drugs will know the numbers of the relevant pockets and none of the researchers or patients will know the type of medicine each person receives. The first person will be given pocket number 1, which will continue until completion. soft gels will be similar in shape, size, color, and, smell.

Based on blocks and allocation sequences each client will be given white pockets that are prepared in equal sizes and on which the numbers 1 to 50 are written (in order of allocation sequence). The pockets will contain white boxes containing Flaxseed and Nigella Sativa, or Placebo capsules. Only the person in charge of packing soft gels will know the numbers of the relevant pockets and none of the researchers or patients will know the type of medicine each person receives. The first person will be given pocket number 1, which will continue until completion. All soft gels will be similar in shape, size, color, and smell.

Intervention group: This group will receive a capsule containing 0.75 ml Flaxseed and 0.75 ml Nigella Sativa soft gels every 12 hours and for 3 months. The capsules will be provided by Sina Noandish Tabiat Company.