Interventional study design. phase 1 clinical trials

Knowledge Research and Innovation Center, Pakistan (KRIC) Online consultation and online questionnaire filled by the participants.

Single intervention group.

1. Fever 2. Cough 3. Sore Throat 4. Shortness of Breath 5. Muscle Pain

درمانی - غیره

Intervention group: Methods: Participants 34 COVID-19 patients with mild to severe symptoms both males and females were selected. Outcomes: Primary Outcomes measuring: symptoms’ intensity; Fever was measured on thermometer scale, the intensity of Cough was measured on Visual Analogue Scale (VAS) , Shortness of Breath was observed on Borg dyspnea scale, Muscle Pain was measured on VAS Scale and Throat Soreness was measure on sore throat scale. Secondary Outcomes effectiveness of the treatment; measuring significance of mean difference of symptoms’ intensity, from day one till day of recovery to a maximum of 12 days. Tertiary Outcomes patient’s satisfaction of the treatment was measured on 5-point Likert scale. Study Setting: Knowledge Research and Innovation Center, Lahore Pakistan. Inclusion Criteria: a. Both genders b. Aged between 18-80 years c. Mild, moderate or severe infection. d. COVID-19 positive on the basis of symptoms, physical test and lab test. Exclusion Criteria a. Any tumor or malignancy b. Recent surgery c. Patient on invasive / non-invasive ventilator (critical) d. Taking any other medicine parallel to PAK-20 and Oniater for treatment of COVID-19.Taking any immunosuppressant. Interventions Experimental group was given 1gm of PAK-20 (containing Cloves, Black pepper, Cumin Seed, Cinnamon, Black cardamom, Mace Spice, Nutmeg, Star anise and Bay leaves) in 250ml of Combo 1 (soup/meat stock) twice a day for a maximum of 12 days, 50 ml of Oniater (onion water) once a day for consecutive 3 days and 250ml of Combo 2 (herbal tea) containing cloves, black pepper, green cardamom, black cardamom, stick of cinnamon, ginger slice, fennel seeds and half lemon juice twice a day for a maximum of 12 days. Datseed containing date filled with black seeds (kalonji) was given once a day for a maximum of 12 days. Ajwa dates seed powder (market available herbal compound) was given to specifically those patients who were already suffering from diabetes, cardiovascular disease or hyperlipidemia. Use of fruits; like Apples, Mangoes, pure organic juices; like carrot juice, orange juice, apple juice, mango milk shake even beyond 12 days until strength was restored. Meat/ lentils use for intake of proteins till recovery. Use of 70gm of Talbina once per day that increases 94 kcal, served as powerful energy diet.

The Universal Trial Number (UTN) is U1111-1262-7419