بررسی و مقایسه اثر وعده غذایی پرپروتئین پر چرب و پر پروتئین پر کربوهیدرات برمتابولیسم استراحت و فاکتورهای متابولیک در بالغین دارای اضافه وزن و چاقی

The clinical trial study is carried out in a cross-over manner and without blinding, and 30 men and women aged 18-65 years received intervention 1 in the first stage, and a week later the same people came again to receive the second intervention. To apply randomization from The method of random blocks will be used with the help of www.randomizer.org

مطالعه کارآزمایی بالینی به صورت متقاطع و بدون کورسازی انجام می شود و ۳۰ نفر زن و مرد 18 -65 سال در مرحله اول مداخله ۱ را دریافت کرده و یک هفته بعد مجدد همین افراد برای دریافت مداخله دوم مراجعه می کنند.برای اعمال تصادفی سازی از روش بلوکهای تصادفی و با کمک سایت www.randomizer.org استفاده خواهد شد

The study is soon to be conducted at the Health Monitoring Center of Imam Reza Hospital in Mashhad. Participants,1 0 hours fasting, will undergo anthropometric evaluation and indirect calorimetry on the day of their visit. Basic blood tests will also be conducted. After the initial evaluation, participants are to consume the first meal within 15 minutes. Subsequently, 15 minutes later, indirect calorimetry and blood sample tests will be performed. Calorimetry and tests are then to be conducted at 1, 2, 3, and 4 hours post-meal as described. One week after the first intervention, the same participants are scheduled to return to receive the second meal, and evaluations will be conducted in the same manner.

Inclusion criteria: All adults with overweight and obesity who do not have any underlying conditions Exclusion criteria: obese and overweight people who have an underlying disease

شرایط ورود: تمام بالغین دارای اضافه وزن و چاقی که بیماری زمینه ای نداشته باشند شرایط عدم ورود: افراد چاق و اضافه وزن که دارای بیماری زمینه ای هستند

Resting Metabolic rate; Respiratory Quotient; Blood Glucose; Thyroid Hormones; Serum Insulin; Lipid profile; Adrenal hormones - Measurement and comparison of appetite within and between groups

متابولیسم استراحت؛ ضریب تنفسی؛ قند خون؛ هورمونهای تیروئیدی؛ انسولین سرم؛ پروفایل لیپیدی؛ هورمون های آدرنال -اندازه گیری و مقایسه اشتها هر گروه و بین گروه ها

2024-10-22, ۱۴۰۳/۰۸/۰۱

2025-01-20, ۱۴۰۳/۱۱/۰۱

One of the devices utilized in this project for assessing resting metabolic rate is the indirect calorimetry device. Considering that access to this device for students of Mashhad University of Medical Sciences is only available at the university’s Employee Health Monitoring Center, and given that the device has been undergoing repairs and was non-operational for some time, as well as the high demand for its use, permission for utilizing the device for this study has only recently been obtained. Therefore, if possible, the patient recruitment phase will be adjusted according to the latest updates.

یکی از ابزار های مورد استفاده در این طرح جهت بررسی resting metabolic rate دستگاه کالری متری غیر مستقیم می باشد. با توجه با اینکه امکان استفاده از دستگاه برای دانشجویان دانشگاه علوم پزشکی مشهد تنها در مرکز پایش سلامت کارکنان این دانشگاه میسر می باشد و نظر به اینکه دستگاه مدتی در حال تعمیر بوده و عملیاتی نبوده است . و بدلیل ترافیک افراد متقاضی استفاده از دستگاه ، اخیرا امکان استفاده از آن برای این مطالعه کسب گردیده است. لذا در صورت امکان دوره بیمارگیری مطابق اصلاحات جدید اعمال خواهد شد.

18 ≤ age <65
25 ≤ BMI <40
Weight stability for 3 months before starting the study (no more than 5% weight loss or weight gain)
Without history of bariatric surgery
No use of weight loss medicine in the last 6 months
Not using a weight loss diet in the last 3 months
The participant should be in complete health, as stated by the individual. They should not have known gastrointestinal diseases and reflux, diabetes, hypertension, cardiovascular diseases, Liver and Kidney disorders, or lipid disorders, nor should they be taking medications related to these conditions. Additionally, they should not be using thyroid medications or other drugs that affect metabolism.
Should not engage in intense physical activity and should not be professional athletes (MET-min/week > 600)
Should not have addiction to drugs or alcohol
Should not have mental health disorders such as depression and eating disorders
Should not be pregnant or breastfeeding
Willingness to Lose Weight and Consent to Participate in the Program

Intense physical activity before the study
Not fasting before intervention
Unbalanced diet in terms of composition of macronutrients in the last 24 hours
Continuous use of any drug (especially drugs that affect metabolism such as thyroid drugs, drugs that affect Adrenals such as corticosteroids or drugs and alcohol on a continuous basis)
Reluctance to cooperate
Kidney disorders, Liver failure, lipid profile disorders, lack of micronutrients

Overweight and Obesity

Resting Metabolic Rate is measured at the beginning of the study, 1, 2, 3 and 4 hours after the intervention.

Respiratory quotient

Similar to measuring Resting Metabolic Energy

Similar to measuring Resting Metabolic Energy

Similar to measuring Resting Metabolic Energy

Similar to measuring Resting Metabolic Energy

گروه مداخله: در مرحله اول به افراد یک نوبت وعده غذایی پر پروتئین(25درصد) پر چرب(45درصد) کم کربوهیدرات (30درصد) داده می شود. کالری این وعده بر اساس ۲۵درصد انرژی مورد نیاز روزانه فرد محاسبه می شود.

گروه کنترل: در مرحله دوم به همان افراد شرکت کننده در مرحله اول به عنوان گروه کنترل وعده غذایی پر پروتئین (25درصد) کم چرب (15درصد) پر کربوهیدرات (60درصد) داده می شود. کالری این وعده نیز بر اساس ۲۵درصد انرژی مورد نیاز روزانه فرد محاسبه می شود.