بررسی اثر نانوکورکومین بر سوختگی پوست بیماران ناشی از رادیوتراپی سرطان پستان

The present study will be done on patients undergoing breast cancer radiotherapy referred to the Yasrebi Hospital, Kashan, Iran in 2020-2021. The patients will be treated with standard radiotherapy regimen of one fraction per day, 5 days a week, 25 treatment fractions (5 weeks), radiation dose per faction of 200 cGy and a total radiation dose of 5000 cGy. The patients will take Nano-curcumin capsules in order to reduce radiation-induced skin reactions. 42 patients with easy sampling were entered and divided by a mixture of 2 and 4 randomized blocks into two groups of control and treated with Nano-curcumin. The patient will be unaware of the type of medication prescribed.The control group will only receive a standard radiotherapy regimen and treatment group will receive a standard radiotherapy regimen plus Nano-curcumin. The patients will receive Nano-curcumin from the first fraction of radiotherapy and continue until the end of the treatment. Finally, skin evaluation of patients will be done weekly by a radiation oncologist.

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Assessment of effect of Nano-curcumin on radiotherapy-induced skin reaction in breast cancer patients

Assessment of effect of Nano-Curcumin on radiotherapy-induced skin reaction in breast cancer patients

Simple randomization 42 patients referred to the Yasrebi radiotherapy center will enter the study with easy sampling. These individuals are then divided into two groups of control and treated with curcumin using a mixture of 2 and 4 randomized blocks.

تصادفی سازی ساده 42 نفر از بیماران مراجعه کننده به بخش رادیوتراپی بیمارستان آیت اله یثربی به صورت نمونه گیری آسان وارد مطالعه خواهند شد. سپس این افراد با استفاده از مخلوطی از بلوکهای تصادفی 2 و 4 تایی به دو دسته شاهد و درمان با داروی کورکومین تقسیم بندی می شوند.

Determination of skin reactionس at the beginning of study (before the intervention), 7, 14, 21, 28 and 35 days after the start of Nano-curcumin capsule consumption

تعیین درجه واکنش پوستی (گرید سوختگی ) بر اساس معیار انجمن رادیوتراپی -آنکولوژی توسط متخصص پرتودرمانی

Intervention group: Nano-curcumin Capsule (Exir Nano Sina Co.) as an 80mg gelatin capsule , one capsule per day after breakfast, from the first radiotherapy fraction to the last radiation therapy fraction.