Efficacy of Racecadotril in the Management of Acute Gastroenteritis in Children

To compare the effectiveness of racecadotril versus placebo in the management of acute gastroenteritis among children with some dehydration

Open labeled, randomized controlled trial

Department of pediatrics, Rai Teaching Hospital, Sargodha, Pakistan.

Inclusion Criteria: Children of both genders, aged between 1 to 18 years, presenting with acute gastroenteritis with some dehydration. Exclusion Criteria: Children with malnutrition, osmotic diarrhea, chronic diarrhea, or bloody diarrhea. Immunocompromised children, and children having severe dehydration

Children in Racecadotril group were given oral rececadotril in addition to the standard WHO treatment for acute gastroenteritis. Children in Placebo group were given only the standard WHO treatment along with 5 ml of distilled water in the form of a placebo for acute gastroenteritis. Both groups were given designated treatments for a duaration of 3 days.

Reduction in number of stools

Randomization was done using envelop system. The envelopes were shuffled to ensure randomness. The envelopes were opened one by one, and each participant was allocated to either the Racecadotril group or the Placebo group. This process ensured that each participant had an equal chance of being assigned to either group, reducing the potential for bias in the assignment process. Children in Racecadotril group were given oral rececadotril in addition to the standard WHO treatment for acute gastroenteritis. Children in Placebo group were given only the standard WHO treatment along with 5 ml of distilled water in the form of a placebo for acute gastroenteritis.

Not applicable

6 months after publication

All

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Contact corresponding author

Contact corresponding author