]>
IRCT201306189175N5 IRCT 2013-07-12 Vice chancellor for research, Mashhad University of Medical Sciences Comparison of effect of bupropion and venlafaxine in children with hyperactivity Comparison of therapeutic effect of bupropion and venlafaxine in children with Attention deficit hyperactivity disorder 2011-12-19 anticipated 40 Complete https://irct.ir/trial/9785 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention. 2-3 Attention deficit hyperactivity disorder. Intervention 1: First group: The patients will be received ritalin with previous dose beside venlafaxine 0.5 mg to Kg weight during the first week. In the second week, half of the first week ritalin dose beside venlafaxine will be given. Venlafaxine dose of 0.1 mg per kg body weight per week is increased till reach to 1.4 mg per kg body weight in the tenth week. Ritalin is deleted from the third week onwards. Intervention 2: For the second group: In the first week of 1.4 mg per kg body weight bupropion (beside previous dose ritalin) is given. In the second week, half of the Ritalin dosage beside 1.91 mg per kg body weight bupropion is given. From the second week, 0.51 mg per kg body weight of bupropion is added every week till received to 6 mg per kg of body weight. Ritalin is deleted from the third week onwards.
public Dr Peiman Hashemian
Ibn-e-Sina psychiatric Hospital, Horre ameli avenue, boo Ali square
Mashhad Iran (Islamic Republic of) +98 51 1888 2926 hashemianp@mums.ac.ir Mashhad University of Medical Sciences scientific Dr Peiman Hashemian
Ibn-e-Sina psychiatric Hospital, Horre ameli avenue, boo Ali square
Mashhad Iran (Islamic Republic of) +98 51 1888 2926 hashemianp@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: Children with attention deficit hyperactivity disorder between 7 to 10 years old with IQ more than 70 by Rion quiz and have not any psychiatric and neurological problem at interview. Exclusion criteria: Children with attention deficit hyperactivity disorder lower than 7 years old and more than 10 years old, IQ lower than 70 and any psychiatric and neurological problem at interview. 7 years 10 years Both F90.0, F90 Attention deficit: disorder with hyperactivity, hyperactivity disorder and syndrome with hyperactivity Treatment - Drugs Treatment - Drugs First group: The patients will be received ritalin with previous dose beside venlafaxine 0.5 mg to Kg weight during the first week. In the second week, half of the first week ritalin dose beside venlafaxine will be given. Venlafaxine dose of 0.1 mg per kg body weight per week is increased till reach to 1.4 mg per kg body weight in the tenth week. Ritalin is deleted from the third week onwards. For the second group: In the first week of 1.4 mg per kg body weight bupropion (beside previous dose ritalin) is given. In the second week, half of the Ritalin dosage beside 1.91 mg per kg body weight bupropion is given. From the second week, 0.51 mg per kg body weight of bupropion is added every week till received to 6 mg per kg of body weight. Ritalin is deleted from the third week onwards. Percentage of response to treatment. Timepoint: before the study, after each two weeks and after completing the study. Method of measurement: Connors Parent Questionnaire. Percentage of response to treatment. Timepoint: before the study, after each two weeks and after completing the study. Method of measurement: Clinical Global Impression Scale. Percentage of response to treatment. Timepoint: before the study, after each two weeks and after completing the study. Method of measurement: Attention deficit hyperactivity disorder rating scale IV. Vice chancellor for research, Mashhad University of Medical Sciences Approved 2011-04-06 Ethics committee of Mashhad University of Medical Sciences Central Building of Mashad University of Medical Sciences Mashhad Iran (Islamic Republic of)