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IRCT201702239014N145 IRCT 2017-03-04 Vice-chancellor for Research the Technology, Hamadan University of Medical Sciences Comparison of the effect of magnesium sulfate versus Dexmedetomidine on the quality of surgical filed in patients candidate for endoscopic sinus surgery Comparison of the effect of magnesium sulfate versus Dexmedetomidine on the quality of surgical filed in patients candidate for endoscopic sinus surgery: a triple blind randomized clinical trial 2017-03-10 anticipated 60 Complete https://irct.ir/trial/9583 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: Randomization: The patients will be randomly assigned to intervention and control groups using block randomization. Blinding: Patients will be unaware of the type of intervention. The physician who will examine the patients will not be aware of the intervention. The analyzer will be unaware of the type of interventions. Therefore, the trial will be run as triple blind. 2 candidate for endoscopic sinus surgery. Intervention 1: Intervention group 1: Magnesium sulfate infusion 50 mg/kg/ min for 10 min and then 15 mg/kg/h to the end of surgery. Intervention 2: Intervention group 2: Dexmedetomidine infusion 1 micg/kg/ min for 10 min and then 0.5 micg/kg/h to the end of surgery.
public Dr Mahdi Shahabi Nejad
Besat Hospital, Shahed Square
Hamadan Iran (Islamic Republic of) +98 81 3838 0090 mshahabi84@yahoo.com Besat Hospital scientific Dr Ebrahim Khoshraftar
Besat Hospital, Shahed Square
Hamadan Iran (Islamic Republic of) +98 81 3364 0030 khoshraftar@umsha.ac.ir Besat Hospital Iran (Islamic Republic of) Inclusion criteria: Patients candidate for endoscopic sinus surgery; age of 18 to 60 years. Exclusion criteria: Obesity with BMI index equal to or greater than 30; renal, liver, hematological, neuromuscular or hemorrhagic disorders; diabetes; using calcium blocker or NSAIDS. 18 years 60 years Both Y60.4 During endoscopic examination Treatment - Drugs Treatment - Drugs Intervention group 1: Magnesium sulfate infusion 50 mg/kg/ min for 10 min and then 15 mg/kg/h to the end of surgery. Intervention group 2: Dexmedetomidine infusion 1 micg/kg/ min for 10 min and then 0.5 micg/kg/h to the end of surgery. Measuring bleeding. Timepoint: at 1, 5, 15, 30 and 60 minutes after starting infusion. Method of measurement: using suction. Vice-chancellor for Research the Technology, Hamadan University of Medical Sciences Approved 2015-06-20 Ethics Committee of Hamadan University of Medical Sciences Vice-chancellor for Research the Technology, Hamadan University of Medical Sciences, Shahid Fahmideh Ave Hamadan Iran (Islamic Republic of)