IRCT201609209014N117 IRCT 2016-09-22 Vice-chancellor for Research the Technology, Hamadan University of Medical Sciences Comparison the effect of the topical Plantago major hydro-alcoholic extract versus placebo on treatment of grade1 pressure ulcer in patients with paralysis secondary to brain stroke Comparison the effect of the topical Plantago major hydro-alcoholic extract versus placebo on treatment of grade1 pressure ulcer in patients with paralysis secondary to brain stroke: a triple blind randomized clinical trial 2016-10-06 anticipated 112 Complete https://irct.ir/trial/9555 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Other design features: Randomization: The patients will be randomly assigned to intervention and control groups using block randomization. Blinding: Patients will be unaware of the type of intervention. The physician who will examine the patients will not be aware of the intervention. The analyzer will be unaware of the type of interventions. Therefore, the trial will be run as triple blind. 2 Stroke. Intervention 1: Using topical Phenytoin cream 1% on the grade 1 pressure ulcers once a day for 2 weeks plus Plantago major hydro-alcoholic extract once a day for 2 weeks. Intervention 2: Using topical Phenytoin cream 1% on the grade 1 pressure ulcers once a day for 2 weeks plus placebo once a day for 2 weeks.