]>
IRCT201606239014N103 IRCT 2016-07-01 Vice-chancellor for Research the Technology, Hamadan University of Medical Sciences Effect of narrow band UVB in combination with 0.1% topical Tacrolimus versus narrow band UVB alone on treatment of patients with vitiligo Effect of narrow band UVB in combination with 0.1% topical Tacrolimus versus narrow band UVB alone on treatment of patients with vitiligo: a double blind randomized clinical trial 2016-07-10 anticipated 25 Complete https://irct.ir/trial/9541 interventional Randomization: Not randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Other design features: Randomization: Each patients will be his/her own control. For this purpose, the lesions of one side of the body will be randomly treated with combination therapy and the other side will be treated with placebo. Blinding: Patients will be unaware of the type of topical ointment. The physician who will examine the lesions will not be aware of the intervention. Therefore, the trial will be run as double blind. 2 Vitiligo. Intervention 1: narrow band UVB at a dose of 0.5 to 1 j/cm2 plus 0.1% Tacrolimus topical ointment twice a day for 3 months. Intervention 2: narrow band UVB at a dose of 0.5 to 1 j/cm2 plus Eucerin (placebo) topical ointment twice a day for 3 months.
public Dr Bahareh Ebrahimi
Farshchian Hospital, Mirzadeh Eshghi Ave.
Hamadan Iran (Islamic Republic of) +98 81 3827 4184 dr_ebrahimi_b@yahoo.com Farshchian Hospital scientific Dr Amaneh Yazdanfar
Farshchian Hospital, Mirzadeh Eshghi Ave.
Hamadan Iran (Islamic Republic of) +98 81 3827 4184 amyazdanfar2000@yahoo.com Farshchian Hospital Iran (Islamic Republic of) Inclusion criteria: presence of bilateral symmetrical vitiligo lesions on upper and lower limbs, face or trunk; fixed or progressive disease process; involvement of at least 10 percent body surface. Exclusion criteria: using topical treatments in the past one month; immunodeficiency; any contraindication of phototherapy. no limit no limit Both L80 Vitiligo Treatment - Drugs Placebo narrow band UVB at a dose of 0.5 to 1 j/cm2 plus 0.1% Tacrolimus topical ointment twice a day for 3 months narrow band UVB at a dose of 0.5 to 1 j/cm2 plus Eucerin (placebo) topical ointment twice a day for 3 months Measuring vitiligo score. Timepoint: before intervention and 1.5 and 3 months after intervention. Method of measurement: using VASI scoring scale. Assessing local adverse events (erythema and inflammation). Timepoint: 1.5 and 3 months after intervention. Method of measurement: through physical examination. Vice-chancellor for Research the Technology, Hamadan University of Medical Sciences Approved 2016-05-15 Ethics Committee of Hamadan University of Medical Sciences Vice-chancellor for Research the Technology, Hamadan University of Medical Sciences, Shahid Fahmideh Ave Hamadan Iran (Islamic Republic of)