IRCT201411269014N50 IRCT 2014-12-02 Vice-chancellor for Research the Technology, Hamadan University of Medical Sciences Effect of celecoxib and ibuprofen versus placebo on pain after laparotomy in drug dependence Effect of celecoxib and ibuprofen versus placebo on pain after laparotomy in drug dependence: a double-blind randomized clinical trial 2013-09-23 anticipated 114 Complete https://irct.ir/trial/9489 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Other design features: Randomization: random assignment of the patients systematically one at a time to intervention and control groups. Blinding: drugs have no label thus patients will not be aware of the type of treatment they receive. In addition, the examiner who will examine the patients is another person that will not be aware of the type of intervention. Therefore, the trial will be run as double blinded. 2 Pain. Intervention 1: 200 mg oral celecoxib single dose 1 hour before surgery. Intervention 2: 400 mg oral ibuprofen single dose 1 hour before surgery. Intervention 3: one tablet of vitamin B single dose 1 hour before surgery.