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IRCT201402269014N26 IRCT 2014-03-09 Vice-chancellor for Research the Technology, Hamadan University of Medical Sciences Effect of narrow band UVB phototherapy plus betamethasone ointment versus narrow band UVB phototherapy plus placebo ointment on the treatment of vitiligo Effect of narrow band UVB phototherapy plus betamethasone ointment versus narrow band UVB phototherapy plus placebo ointment on the treatment of vitiligo: a double blinded randomized clinical trial 2012-05-21 anticipated 30 Complete https://irct.ir/trial/9465 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Other design features: Randomization: Two symmetrical lesions on either side of each patient are randomly selected, one as intervention and the other as control. Thus, each patient will be compared with oneself. Blinding: The patients will receive ointment with the same shape but different content. Thus, they will not aware of the intervention. The photos will be taken from the lesions in the sixth and twelfth weeks. Then the photos will be evaluated and compared with each other by a physician who is not aware of the intervention. Thus, the design of the study will be double blinded. 2-3 Vitiligo. Intervention 1: Narrow band UVB phototherapy thrice a week plus betamethasone ointment twice a day for three months. Intervention 2: Narrow band UVB phototherapy thrice a week plus placebo (eucerin) ointment twice a day for three months.
public Dr Azam Dalirad
Farshchian Hospital, Mirzadeh Eshghi Ave
Hamadan Iran (Islamic Republic of) 00 a.delirrad@gmail.com Farshchian Hospital scientific Dr Amaneh Yazdanfar
Farshchian Hospital, Mirzadeh Eshghi Ave
Hamadan Iran (Islamic Republic of) 00 yazdanfar@usmsha.ac.ir Farshchian Hospital Iran (Islamic Republic of) Inclusion criteria: (a) age of 7 years or older; (b) having bilateral symmetrical vitiligo lesions on upper or lower limbs, face, or trunk; (c) the vitiligo is either stable or progressive; (d) at least 10% of the body surface is affected by the disease. Exclusion criteria: (a) being immunodeficient; (b) being spontaneous repigmentation; (c) having any contraindications for phototherapy. 7 years 60 years Both L80 Vitiligo Treatment - Drugs Placebo Narrow band UVB phototherapy thrice a week plus betamethasone ointment twice a day for three months. Narrow band UVB phototherapy thrice a week plus placebo (eucerin) ointment twice a day for three months. Repigmentation of the lesion. Timepoint: at the sixth and twelfth weeks. Method of measurement: based on VASI criteria. Evaluation of probable superficial burn. Timepoint: weekly before phototherapy. Method of measurement: through clinical observation. Vice-chancellor for Research the Technology, Hamadan University of Medical Sciences Approved 2012-05-16 Research Ethic Committee of Hamadan University of Medical Sciences Vice-chancellor of Research the Technology, Hamadan University of Medical Sciences, Shahid Fahmideh Ave Hamadan Iran (Islamic Republic of)