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IRCT201604261556N89 IRCT 2016-12-28 Vice Chancellor for research, Tehran University of Medical Science Effect of local endometrial injury in women with unsuccessful IVF improve on pregnancy rate Effect of local endometrial injury in women with one and two failure history in IVF cycle on success rate of embryo implantation and pregnancy 2016-12-24 anticipated 70 Complete https://irct.ir/trial/938 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: Randomization is based on randomized blocks. N/A infertility. Intervention 1: In intervention group, patients are treated with Local endometrial injury (LEI) with standard Pipelle biopsy before IVF procedure in luteal phase of menstrual cycle.Then patients are treated with increasing dose of 2, 3 and 4 mg progesterone valerate suppository for 14 days. After trans vaginal sonography, if endometrial thickness is more than 7 mm, progesterone cyclogest is administered and 5 days later embryo transfer is done. Intervention 2: Control group: IVF procedure is performed without LEI.
public Soodeh Khorasani
Arash Women Hospital, Rashid Street, Resalat Highway,Tehranpars
Tehran Iran (Islamic Republic of) +98 21 7771 9922 soodeh.khorasani@yahoo.com Tehran University of Medical Science scientific Sahin Akhonzadeh
Roozbeh Psychiatric Hospital
Tehran Iran (Islamic Republic of) +98 21 6641 8466 s.akhond@sina.tums.ac.ir Tehran University of Medical Science Iran (Islamic Republic of) Inclusion criteria: Age<40 years old; normal uterine cavity in hysteroscopy and Hysterosalpingography in last year; BMI<30; one or two IVF failure; not taking OCP or GnRH for FET in past cycle; patient had indication for EI Exclusion criteria: known intrauterine factors in sonography or imaging as fibroma ; endometrial hyperplasia ; cancer; active vaginal and cervical infection; presence of hydrosalpinx or systemic disorders 15 years 40 years Female Z31.2 Admission for harvesting or implantation of ova Treatment - Other Treatment - Other In intervention group, patients are treated with Local endometrial injury (LEI) with standard Pipelle biopsy before IVF procedure in luteal phase of menstrual cycle.Then patients are treated with increasing dose of 2, 3 and 4 mg progesterone valerate suppository for 14 days. After trans vaginal sonography, if endometrial thickness is more than 7 mm, progesterone cyclogest is administered and 5 days later embryo transfer is done. Control group: IVF procedure is performed without LEI. Pregnancy. Timepoint: 2 weeks after IVF. Method of measurement: beta HCG test. Implantation. Timepoint: 5 weeks after IVF. Method of measurement: sonography. Vice Chancellor for research, Tehran University of Medical Science Approved 2015-10-29 Ethics committee of Tehran University of Medical Science Qods Street, Keshavarz Bulevard Tehran Iran (Islamic Republic of)