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IRCT20260915071060N1 IRCT 2026-10-03 Esfahan University of Medical Sciences Comparison of the Effectiveness of Acceptance and Commitment Therapy and Compassion-Focused Therapy on Relapse Risk and Craving in Amphetamine/Methamphetamine Users Comparison of the Effectiveness of Acceptance and Commitment Therapy and Compassion-Focused Therapy on Relapse Risk and Craving in Amphetamine/Methamphetamine Users 2021-06-22 anticipated 45 Complete https://irct.ir/trial/93365 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Based on the article text (sud.docx), the randomization process was conducted using the specialized "Random Allocation Software." The details are as follows: Implementation method: Following the initial selection of participants and the verification of inclusion criteria, the researchers used the aforementioned software to assign participants to different groups. Grouping: Participants were randomly divided into three main groups: Intervention Group 1: Acceptance and Commitment Therapy (ACT) Intervention Group 2: Compassion-Focused Therapy (CFT) Control Group The use of this software in clinical trials is a standard and valid method employed to minimize bias in participant selection and group allocation, thereby enhancing the study's internal validity, Blinding description: Package coding: Medications are dispensed by an independent pharmacist or a random coding system with coded labels so that the doctor and patient can code A or B without knowing the nature of the medication. N/A Amphetamine use disorder. Intervention 1: Intervention group: Intervention group: Act psychotherapy treatment. Intervention 2: Intervention group: Intervention name (title): Acceptance and Commitment Therapy (ACT) with the Matrix Basic Model. Intervention description: In addition to receiving 8 weekly sessions of the Matrix Model (relapse prevention education, healthy lifestyle, and self-help programs), patients in this group underwent 8 weekly sessions of individual Acceptance and Commitment Therapy (ACT) for 45 minutes per session. The sessions were conducted by a psychiatrist who was proficient in the intervention, and the patients were followed up twice, two weeks apart. Intervention group: First session: Clinical interview, case conceptualization, and training on how the mind works. Second session: Examining ineffective strategies of mental restraint and control using the "tug-of-war" exercise and metaphor. Third session: Creating creative hopelessness through the "farm of life" metaphor. Fourth session: Psychoeducation of the inner and outer world, distinguishing between pure and impure suffering, using the "sensitive device" metaphor, and the "1-2-3" experimental exercise. Fifth session: Promoting psychological acceptance and willingness with the "uninvited guest" metaphor and identifying cognitive errors with the "bus" metaphor. Sixth session: Self-as-Context exercise and mindfulness of the conceptualized self using the "chessboard" and "billboard" metaphors. Intervention 3: Intervention group: Intervention group 2 (Compassion-Focused Therapy - CFT) (Create a new box by clicking the Add button and entering the following text) Intervention name (title): Compassion-Focused Therapy (CFT) with the basic matrix model Intervention description: In addition to 8 weekly sessions of the matrix model, patients in this group underwent 8 weekly sessions of individual compassion-focused psychotherapy (CFT) for 45 minutes per session by the same psychiatrist, and follow-up was conducted twice with two-week intervals. Title and content of CFT sessions: Intervention group: First session: Conclusion of a therapeutic contract, diagnostic compassion interview, providing feedback, and the first step of formulation and conceptualization. Second session: Second step of conceptualization based on the cultural context and history of the client, creating empathy and feedback based on compassion. Third session: Third step of conceptualization, functional analysis of different areas of life and identification of the pathological vicious cycle and unkindness to oneself. Fourth session: Training in the ancient/modern/conscious brain model and the triple model of motivation And the emotion of compassion to enhance the client's motivation to move towards compassion. Session Five: Explaining the effect of kindness and compassion in stopping the cycle of blaming and unkindness to oneself and the mind. Session Six: Conceptualizing and activating the "Compassionate Self", teaching its characteristics and comparing it with other vulnerable parts of the self. Session Seven: Assessing the alignment of the compassionate self with life values, reviewing caring for individual well-being with the "One Great Day" exercise, identifying internal/external barriers, and teaching compassion-based behaviors. Session Eight: Revisiting the conceptualization matrix, reviewing the disease cycle and ways to prevent the return of symptoms, teaching life practice, and assessing readiness and periodic follow-up. Intervention 4: Control group: Control group: Participants in this group received only the standard and basic substance withdrawal program (including 8 weekly sessions of the Matrix model aimed at teaching temptation and relapse prevention, healthy lifestyle, and participation in self-help programs) and no specific additional individual psychotherapy intervention (either ACT or CFT) was implemented for them. The initial assessment and follow-up of this group were conducted simultaneously with the two intervention groups (immediately after the course and follow-ups at two-week intervals) using the Relapse Prediction Questionnaire (RPS). Yes - There is a plan to make this available What will be shared: There is a plan for the publication of approved items. When: One year To whom: Medical students and professors Conditions: The best way to increase knowledge and awareness is through registration in a reputable scientific journal. Where to obtain: Registration in a reputable journal How to obtain: By searching other similar articles Comments:
public Dr.Elham mohebati
Isfahan University of Medical Sciences
Isfahan Iran (Islamic Republic of) 81746-73461 +98 31 3633 0642 dr.eli.mohebati.1983@gmail.com Esfahan University of Medical Sciences scientific Dr.Elham mohebati
Isfahan University of Medical Sciences
Isfahan Iran (Islamic Republic of) 81746-73461 +98 31 3633 0642 dr.eli.mohebati.1983@gmail.com Esfahan University of Medical Sciences Iran (Islamic Republic of) Age range: 18 to 50 years. Place of residence: Resident of Isfahan Education: Minimum of a high school diploma. Diagnosis: Confirmed diagnosis of amphetamine abuse or dependence (without abuse of other substances or alcohol). Treatment history: No pharmacological or psychological intervention for substance abuse in the past six months. 18 years 65 years Both Absence from sessions: Missing three or more treatment sessions (intervention protocol). Relapse: Experiencing any relapse or return to amphetamine use during the intervention period. Non-cooperation: Expression of unwillingness to participate or discontinuation of cooperation by the participant during the course of treatment. F15.2 Other stimulant dependence Treatment - Other Treatment - Other Treatment - Other Treatment - Other Intervention group: Intervention group: Act psychotherapy treatment Intervention group: Intervention name (title): Acceptance and Commitment Therapy (ACT) with the Matrix Basic Model. Intervention description: In addition to receiving 8 weekly sessions of the Matrix Model (relapse prevention education, healthy lifestyle, and self-help programs), patients in this group underwent 8 weekly sessions of individual Acceptance and Commitment Therapy (ACT) for 45 minutes per session. The sessions were conducted by a psychiatrist who was proficient in the intervention, and the patients were followed up twice, two weeks apart. Intervention group: First session: Clinical interview, case conceptualization, and training on how the mind works. Second session: Examining ineffective strategies of mental restraint and control using the "tug-of-war" exercise and metaphor. Third session: Creating creative hopelessness through the "farm of life" metaphor. Fourth session: Psychoeducation of the inner and outer world, distinguishing between pure and impure suffering, using the "sensitive device" metaphor, and the "1-2-3" experimental exercise. Fifth session: Promoting psychological acceptance and willingness with the "uninvited guest" metaphor and identifying cognitive errors with the "bus" metaphor. Sixth session: Self-as-Context exercise and mindfulness of the conceptualized self using the "chessboard" and "billboard" metaphors. Intervention group: Intervention group 2 (Compassion-Focused Therapy - CFT) (Create a new box by clicking the Add button and entering the following text) Intervention name (title): Compassion-Focused Therapy (CFT) with the basic matrix model Intervention description: In addition to 8 weekly sessions of the matrix model, patients in this group underwent 8 weekly sessions of individual compassion-focused psychotherapy (CFT) for 45 minutes per session by the same psychiatrist, and follow-up was conducted twice with two-week intervals. Title and content of CFT sessions: Intervention group: First session: Conclusion of a therapeutic contract, diagnostic compassion interview, providing feedback, and the first step of formulation and conceptualization. Second session: Second step of conceptualization based on the cultural context and history of the client, creating empathy and feedback based on compassion. Third session: Third step of conceptualization, functional analysis of different areas of life and identification of the pathological vicious cycle and unkindness to oneself. Fourth session: Training in the ancient/modern/conscious brain model and the triple model of motivation And the emotion of compassion to enhance the client's motivation to move towards compassion. Session Five: Explaining the effect of kindness and compassion in stopping the cycle of blaming and unkindness to oneself and the mind. Session Six: Conceptualizing and activating the "Compassionate Self", teaching its characteristics and comparing it with other vulnerable parts of the self. Session Seven: Assessing the alignment of the compassionate self with life values, reviewing caring for individual well-being with the "One Great Day" exercise, identifying internal/external barriers, and teaching compassion-based behaviors. Session Eight: Revisiting the conceptualization matrix, reviewing the disease cycle and ways to prevent the return of symptoms, teaching life practice, and assessing readiness and periodic follow-up. Control group: Control group: Participants in this group received only the standard and basic substance withdrawal program (including 8 weekly sessions of the Matrix model aimed at teaching temptation and relapse prevention, healthy lifestyle, and participation in self-help programs) and no specific additional individual psychotherapy intervention (either ACT or CFT) was implemented for them. The initial assessment and follow-up of this group were conducted simultaneously with the two intervention groups (immediately after the course and follow-ups at two-week intervals) using the Relapse Prediction Questionnaire (RPS). Comparing the effectiveness of CFT with ACT. Timepoint: Two months. Method of measurement: Questionnaire. Esfahan University of Medical Sciences Approved 2024-06-08 This study was designed in accordance with the principles of the Declaration of Helsin Isfahan University of Medical Sciences Isfahan Isfehan Iran (Islamic Republic of)