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IRCT20120129008863N17 IRCT 2026-08-25 Vice Presidency for Research and Technology, Hakim Sabzevari University Comparative Effects of Small-Sided Games with and without Coenzyme Q10 Supplementation on Oxidative Stress Markers Comparative Effects of Small-Sided Games with and without Coenzyme Q10 Supplementation on Oxidative Stress Markers in Soccer Players 2026-09-11 anticipated 20 Recruiting https://irct.ir/trial/92728 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Used, Assignment: Parallel, Purpose: Health service research, Randomization description: This study utilizes a simple individual-level randomization method, where 20 participants are randomly assigned to two groups (high-intensity interval training with CoQ10 supplementation and training with placebo). A computer-generated sequence is used for random allocation to ensure high precision and reproducibility while minimizing selection bias, Blinding description: This study is a single-blind clinical trial in which blinding applies exclusively to the CoQ10 and placebo administration. Participants read the research protocol during the first session, and the supplement and placebo, provided in identical capsules, are distributed among them such that only the researcher is aware of the capsule contents. N/A Inflammation in Football Players. Intervention 1: Intervention group: Intervention Group 1 (Training + Supplementation): Participants in this group will engage in a 6-week small-sided games training program while receiving the active supplement. The training protocol consists of three sessions per week, with each session lasting 60 minutes in total (including a 10-minute warm-up, 40 minutes of main training, and a 10-minute cool-down). Concurrently, subjects will consume one 100 mg CoQ10 capsule daily (manufactured by Rosedarou Pharmaceutical Co., Iran) approximately 2 to 4 hours prior to exercise. All training sessions will be conducted under the direct supervision of a certified coach. Intervention 2: Control group: Intervention Group 2 (Training + Placebo): Participants in this group will perform the identical 6-week small-sided games training protocol (3 sessions per week, 60 minutes per session). Instead of CoQ10, they will consume one placebo capsule daily (containing canola oil, manufactured by Rosedarou Pharmaceutical Co., Iran). The placebo capsules are identical in physical appearance to the CoQ10 capsules to maintain blinding. All training sessions will be conducted under the direct supervision of a certified coach to ensure safety and protocol adherence. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is The reasons for the current refusal to share Individual Participant Data (IPD) are: Preserving Confidentiality: Ensuring the highest level of confidentiality and privacy for the participants, which is the principal priority of the research team. Resource Constraints: The lack of adequate financial and human resources to perform the complex processes of preparing, standardizing, and completely anonymizing the raw data sets.
public Dr. Keyvan Hejazi
Hakim Sabzevari University Campus, Tohid Town, Sabzevar
Sabzevar Iran (Islamic Republic of) 9617976487 +98 51 4401 2767 k.hejazi@hsu.ac.ir Hakim Sabzevari University scientific Dr. Keyvan Hejazi
Hakim Sabzevari University Campus, Tohid Town, Sabzevar
Sabzevar Iran (Islamic Republic of) 9617976487 +98 51 4401 2767 k.hejazi@hsu.ac.ir Hakim Sabzevari University Iran (Islamic Republic of) Having at least 2 years of continuous and organized participation in soccer Being in full physical health (confirmed by the PAR-Q health questionnaire) No consumption of any antioxidant, vitamin, or anti-inflammatory supplements within 3 months prior to the study Adherence to a regular diet and non-use of tobacco and alcohol 18 years 20 years Male Absence from more than two consecutive sessions or 10% of total training sessions Significant dietary changes or unauthorized use of ergogenic supplements during the intervention period Occurrence of sports injuries preventing continuation of the training protocol Contracting infectious or viral illnesses during the study period that could alter inflammatory and oxidative markers. Z00.6 Encounter for examination for normal comparison and control in clinical research program Rehabilitation Rehabilitation Intervention group: Intervention Group 1 (Training + Supplementation): Participants in this group will engage in a 6-week small-sided games training program while receiving the active supplement. The training protocol consists of three sessions per week, with each session lasting 60 minutes in total (including a 10-minute warm-up, 40 minutes of main training, and a 10-minute cool-down). Concurrently, subjects will consume one 100 mg CoQ10 capsule daily (manufactured by Rosedarou Pharmaceutical Co., Iran) approximately 2 to 4 hours prior to exercise. All training sessions will be conducted under the direct supervision of a certified coach. Control group: Intervention Group 2 (Training + Placebo): Participants in this group will perform the identical 6-week small-sided games training protocol (3 sessions per week, 60 minutes per session). Instead of CoQ10, they will consume one placebo capsule daily (containing canola oil, manufactured by Rosedarou Pharmaceutical Co., Iran). The placebo capsules are identical in physical appearance to the CoQ10 capsules to maintain blinding. All training sessions will be conducted under the direct supervision of a certified coach to ensure safety and protocol adherence. Glutathione peroxidase. Timepoint: Before the exercise intervention and 6 weeks after the intervention. Method of measurement: Laboratory method: Enzyme-Linked Immunosorbent Assay, using the ZellBio kit (mmol/L). Total Antioxidant Capacity. Timepoint: Before the exercise intervention and 6 weeks after the intervention. Method of measurement: Laboratory method: Enzyme-Linked Immunosorbent Assay, using the ZellBio kit (mmol/L). Vice Presidency for Research and Technology, Hakim Sabzevari University Approved 2026-05-31 Hakim Sabzevari University Hakim Sabzevari University, Tohid Shahr, Sabzevar; Department of Sport Sciences Sabzevar Razavi Khorasan Iran (Islamic Republic of)