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IRCT20231004059615N11 IRCT 2026-08-23 INTERNATIONAL SCIENCE AND TECHNOLOGY UNIVERSITY The effectiveness of caffeine for maximizing hypertrophy and strength in older adults. The effectiveness of pre-exercise caffeine in maximizing hypertrophy and strength gains from morning resistance training in older adults 2026-08-31 anticipated 60 Complete https://irct.ir/trial/92684 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Basic scienece, Randomization description: To minimize potential differences between groups, participants will first be grouped based on their average 1-repetition maximum strength in the squat and bench press. The names of the subjects in each group will be entered into an Excel column; each subject will be randomly assigned a number using the RAND function (=RAND()); then, the numbers will be sorted from smallest to largest. Subjects in each group will then be randomly assigned to one of three groups in a 1:1:1 fashion: caffeine and exercise in the morning, placebo and exercise in the morning, or placebo and exercise in the afternoon, Blinding description: Someone outside the study will prepare the supplement and placebo and will not be known to the participants or researchers until after the data analysis. Also, subjects will receive the supplement and placebo in an opaque capsule with a completely similar appearance and weight, and at the same time of day. 3 Strength training adaptations. Intervention 1: Intervention group 1: MOR-CAF, morning training (08:00) + pre-workout caffeine (4 mg/kg) + daily multi-ingredient supplementation (whey protein, creatine monohydrate, and omega-3 PUFAs). Intervention 2: Intervention group 2: MOR-PLA, morning training (08:00) + pre-workout placebo + daily multi-ingredient supplementation (whey protein, creatine monohydrate, and omega-3 PUFAs). Intervention 3: Control group: AFT-PLA, afternoon training (17:00) + pre-workout placebo + daily multi-ingredient supplementation (whey protein, creatine monohydrate, and omega-3 PUFAs). Yes - There is a plan to make this available What will be shared: All data collected during the study will be shareable after de-identifying the subjects. When: The data will be published after the extracted articles are accepted. To whom: All people Conditions: All data collected during the study will be shareable after de-identifying the subjects. The requester will only be permitted to use the data for meta-analysis reviews. Where to obtain: Corresponding author: Davar Khodadadi, Faculty of Physical Education and Sports Sciences, Islamic Azad University Central Tehran Branch, Tehran, Iran. Email: davar.khodadadi@yahoo.com How to obtain: Sending an email request to the corresponding author: Davar Khodadadi, Email: davar.khodadadi@yahoo.com Comments:
public Davar Khodadadi
Faculty of Physical Education and Sports Sciences, Velayat University Complex, Shahid Sohani St., Sohank
Tehran Iran (Islamic Republic of) 1955847781 +98 21 2263 3583 davar.khodadadi@yahoo.com Islamic Azad University scientific Davar Khodadadi
Faculty of Physical Education and Sports Sciences, Velayat University Complex, Shahid Sohani St., Sohank
Tehran Iran (Islamic Republic of) 1955847781 +98 21 2263 3583 davar.khodadadi@yahoo.com Islamic Azad University Turkey Low habitual caffeine intake (<100 mg/day) Recreationally active but unaccustomed to structured resistance training for the preceding 6 months Not a smoker Not an alcohol drinker 65 years 80 years Both Have uncontrolled cardiovascular, metabolic, or respiratory disease Have severe osteoarthritis Have sleep disorders Current use of medications known to alter neuromuscular function or sleep architecture Lifestyle Lifestyle Placebo Intervention group 1: MOR-CAF, morning training (08:00) + pre-workout caffeine (4 mg/kg) + daily multi-ingredient supplementation (whey protein, creatine monohydrate, and omega-3 PUFAs) Intervention group 2: MOR-PLA, morning training (08:00) + pre-workout placebo + daily multi-ingredient supplementation (whey protein, creatine monohydrate, and omega-3 PUFAs) Control group: AFT-PLA, afternoon training (17:00) + pre-workout placebo + daily multi-ingredient supplementation (whey protein, creatine monohydrate, and omega-3 PUFAs) Body composition. Timepoint: Pre-test and post-test. Method of measurement: Using dual-energy X-ray absorptiometry. Skeletal muscle thickness. Timepoint: Pre-test and post-test. Method of measurement: Using an ultrasound instrument. Mascular strength. Timepoint: Pre-test and post-test. Method of measurement: Using one-repetition maximum test based on the standardized NSCA protocols. Cumulative training volume-load. Timepoint: During the intervention period (all training sessions). Method of measurement: Calculated as the sum of lifted load using the formula (kilograms × repetitions × sets) accumulated during each training session. Sleep quality. Timepoint: Pre-test and post-test. Method of measurement: By the Pittsburgh Sleep Quality Index (PSQI). Sleep efficiency. Timepoint: Pre-test and post-test. Method of measurement: By wrist-worn actigraphy. Functional physical performance. Timepoint: Pre-test and post-test. Method of measurement: Using the Short Physical Performance Battery (SPPB). Muscular endurance. Timepoint: Pre-test and post-test. Method of measurement: By a repetitions-to-failure test on the back squat using a load corresponding to 50% of 1RM. INTERNATIONAL SCIENCE AND TECHNOLOGY UNIVERSITY Approved 2026-08-12 Ethics Committee of the International Science and Technology University Tunahan Mah. Dumlupinar 30 Agustos Cad. No:2, Metromal Business F Blok Office Ankara Ankara Turkey