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IRCT20231004059615N10 IRCT 2026-08-23 International University of Science and Technology The effect of daily resistance training scheduling and caffeine supplementation on training-induced adaptations The effect of daily resistance training scheduling and caffeine supplementation on training-induced adaptations in men who perform recreational resistance training 2026-09-01 anticipated 100 Complete https://irct.ir/trial/92680 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Basic scienece, Randomization description: To minimize potential differences between groups, participants will first be grouped based on their average 1-rep maximum strength in the back squat and bench press. The names of the subjects in each group will be entered into an Excel column; each subject will be randomly assigned a number using the RAND function; then, the numbers will be sorted from smallest to largest. Subjects in each group will then be randomly assigned to one of four groups in a 1:1:1:1 ratio: caffeine plus exercise in the morning, placebo plus exercise in the morning, caffeine plus exercise in the evening, or placebo plus exercise in the evening, Blinding description: Someone outside the study will prepare the supplement and placebo and will not be known to the participants or researchers until after the data analysis. Also, subjects will receive the supplement and placebo in an opaque capsule with a completely similar appearance and weight, and at the same time of day. 3 Condition 1: Resistance Training Adaptations. Condition 2: Circadian Rhythm. Intervention 1: First intervention group: caffeine (4 mg/kg) plus resistance training (3 sessions/week) in the morning (CAFRTm);. Intervention 2: Control group: placebo plus resistance training (3 sessions/week) in the morning (PLARTm);. Intervention 3: Second intervention group: caffeine (4 mg/kg) plus resistance training (3 sessions/week) in the evening (CAFRTe);. Intervention 4: Third intervention group: placebo plus resistance training (3 sessions/week) in the evening (PLARTe). Yes - There is a plan to make this available What will be shared: All data collected during the study will be shareable after de-identifying the subjects. When: The data will be published after the extracted articles are accepted. To whom: All people Conditions: All data collected during the study will be shareable after de-identifying the subjects. The requester will only be permitted to use the data for meta-analysis reviews. Where to obtain: Corresponding author: Davar Khodadadi, Faculty of Physical Education and Sports Sciences, Islamic Azad University Central Tehran Branch, Tehran, Iran. Email: davar.khodadadi@yahoo.com How to obtain: Sending an email request to the corresponding author: Davar Khodadadi, Email: davar.khodadadi@yahoo.com Comments:
public Davar Khodadadi
Faculty of Physical Education and Sports Sciences, Velayat University Complex, Shahid Sohani St., Sohank
Tehran Iran (Islamic Republic of) 1955847781 +98 21 2263 3583 davar.khodadadi@yahoo.com Islamic Azad University scientific Davar Khodadadi
Faculty of Physical Education and Sports Sciences, Velayat University Complex, Shahid Sohani St., Sohank
Tehran Iran (Islamic Republic of) 1955847781 +98 21 2263 3583 davar.khodadadi@yahoo.com Islamic Azad University Turkey Recreationally resistance-trained men; Resistance-training experience ≥6 months and ≤1 year; BMI 18.5–25 kg/m²; Naive caffeine consumers (<25 mg/day). 18 years 35 years Male Suffering from pathology or injury; Taking any medications or nutritional supplements within the past three months; Missing > 5% of the training trials; A history of caffeine intolerance. Lifestyle Placebo Lifestyle Placebo First intervention group: caffeine (4 mg/kg) plus resistance training (3 sessions/week) in the morning (CAFRTm); Control group: placebo plus resistance training (3 sessions/week) in the morning (PLARTm); Second intervention group: caffeine (4 mg/kg) plus resistance training (3 sessions/week) in the evening (CAFRTe); Third intervention group: placebo plus resistance training (3 sessions/week) in the evening (PLARTe). Skeletal muscle hypertrophy. Timepoint: Pre-test and post-test. Method of measurement: By an ultrasound instrument. Body composition. Timepoint: Pre-test and post-test. Method of measurement: By dual-energy X-ray absorptiometry. Mascular strength. Timepoint: Pre-test and post-test. Method of measurement: By one repetition maximum (1RM) test. Muscular endurance. Timepoint: Pre-test and post-test. Method of measurement: By a repetitions-to-failure test on the back squat using a load corresponding to 60% of 1RM. Serum concentrations of total testosterone. Timepoint: Pre-test and post-test. Method of measurement: By enzyme-linked immunosorbent assay (ELISA) kits. Cumulative training volume-load. Timepoint: During the intervention period (all training sessions). Method of measurement: Calculated as the sum of lifted load using the formula (kilograms × repetitions × sets) accumulated during each training session. Serum concentrations of free testosterone. Timepoint: Pre-test and post-test. Method of measurement: By enzyme-linked immunosorbent assay (ELISA) kits. Serum concentrations of IGF-1. Timepoint: Pre-test and post-test. Method of measurement: By enzyme-linked immunosorbent assay (ELISA) kits. Serum concentrations of cortisol. Timepoint: Pre-test and post-test. Method of measurement: By enzyme-linked immunosorbent assay (ELISA) kits. Serum concentrations of Insulin. Timepoint: Pre-test and post-test. Method of measurement: By enzyme-linked immunosorbent assay (ELISA) kits. Serum concentrations of IL-6. Timepoint: Pre-test and post-test. Method of measurement: By enzyme-linked immunosorbent assay (ELISA) kits. Serum concentrations of C-reactive protein. Timepoint: Pre-test and post-test. Method of measurement: By enzyme-linked immunosorbent assay (ELISA) kits. Serum glucose. Timepoint: Pre-test and post-test. Method of measurement: Will be quantified by the enzymatic hexokinase method. Catecholamine response to caffeine and exercise. Timepoint: Pre-test and post-test. Method of measurement: By enzyme-linked immunosorbent assay (ELISA) kits. International University of Science and Technology Approved 2026-08-12 Ethics Committee of the International Science and Technology University F Block Office, Metromal Business , Dumlupinar 30 Agustos Cad No:2, Tunahan Neighborhood Ankara Ankara Turkey