IRCT201201168747N1 IRCT 2012-08-26 Vice chancellor for research, Babol University of Medical Sciences The effect of plasma rich in growth factors in treatment of gingival recession Clinical evaluation of the efficacy of plasma rich in growth factors with connective tissue graft in treatment of gingival recession 2012-05-21 anticipated 22 Complete https://irct.ir/trial/9245 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 2-3 Gingival Recession. Intervention 1: Control group: connective tissue graft with coronally flap advancement. Intervention 2: Intervention group: Moistened connective tissue graft with plasma rich in growth factors and coronally advanced flap.

public Ehsan Zahedi

Babol University of Medical Sciences, No.2, Ganjafruz Avenue

Babol Iran (Islamic Republic of) 4717641367 +98 11 1229 1093 dr.ehsanzahedi@mubabol.ac.ir Babol Dental School scientific Dr. Niloofar Jenabiyan

Babol University of Medical Sciences, Dental School, No.2, Ganjafruz Avenue

Babol Iran (Islamic Republic of) +98 11 1229 1408 dr.ehsanzahedi@mubabol.ac.ir Dental School, Babol University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria : 1) The presence of either bilateral isolated or multiple facial defects with recession depths ≥2 mm when measured from the cementoenamel junction at anterior teeth or premolars; 2) The defects that are judged as Miller Class I or Class II; 3) The selected teeth should be vital, free of restorations or had restorations removed, and with no bleeding upon probing; 4)The age of patients should be within 18 to 65 5) Good oral hygiene (O´Leary plaque score ≤%20 ); 6)Width of keratinized gingiva should be <2 mm; 7) Gingival thickness should be >0.5mm. Exclusion criteria: 1) Smoking; 2) Any uncontrolled local or systemic disease that might contraindicate periodontal surgery; 3) Pregnancy; 4) Hematologic disorders; 5) Usage of the drugs that have intervention with wound healing (corticosteroid, chemotherapeutic agents); 6) Usage of the drugs that have intervention with platelet aggregation; 7) Allergy to tetracycline; 8) Traumatic methods of tooth brushing; 9) Applying abrasive dentifrices; 10) Applying removable partial denture; 11) The history of periodontal surgery at the selected site. 18 years 65 years Both k06.0 Gingival recession (generalized)(localized)(post infective)(post-operative) Treatment - Drugs Treatment - Drugs Control group: connective tissue graft with coronally flap advancement Intervention group: Moistened connective tissue graft with plasma rich in growth factors and coronally advanced flap Gingival recession. Timepoint: Six month after surgery. Method of measurement: Clinical examination. Width of keratinized gingiva. Timepoint: Baseline, 1 and 6 month after surgery. Method of measurement: Clinical examination. Clinical attachment level. Timepoint: Baseline, 1 and 6 month after surgery. Method of measurement: Clinical examination. Clinical probing depth. Timepoint: Baseline, 1 and 6 month after surgery. Method of measurement: Clinical examination. Vertical depth of gingival recession. Timepoint: Baseline, 1 and 6 month after surgery. Method of measurement: Clinical examination. Width of gingival recession. Timepoint: Baseline, 1 and 6 month after surgery. Method of measurement: Clinical examination. Gingival thickness. Timepoint: Baseline, 1 and 6 month after surgery. Method of measurement: Clinical examination. Gingival index. Timepoint: Baseline, 1 and 6 month after surgery. Method of measurement: Clinical examination. The distance between mucogingival junction and cementoenamel junction (Mgjl). Timepoint: Baseline, 1 and 6 month after surgery. Method of measurement: Clinical examination. Vice chancellor for research, Babol University of Medical Sciences Approved 2012-01-05 The ethics committee of Babol University of Medical Sciences Ethics committee of Babol University of Medical Sciences, No.2, Gangafruz Avenue Babol Iran (Islamic Republic of)