IRCT201201078639N1 IRCT 2014-01-10 Vice Chancellor for Research,Hamadan University of Medical Sciences Effect of preemptive novafen on pain relief after impacted tooth surgery Survey of effect of preemptive combination of acetaminophen, ibuprofen and caffeine (novafen) on pain relief and analgesic use after surgery of impacted mandible third molars 2011-12-31 anticipated 108 Complete https://irct.ir/trial/9130 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Other design features: This is a randomized, double-blind study. Randomization and design of the study are as follows: 108 bags were made of dark colors on them were written the numbers 1 to 108. The bags were divided randomly into two groups of 54. Each card was placed inside a bag on which the letter A (the group treated with the combination of 600 mg of ibuprofen 400 mg of acetaminophen and 15 mg caffeine) or the letter B (placebo group) was written. The letter A or B, which was placed inside the bags were determined using random numbers table. So 54 bags containing the letter A and The 54 bags containing the letters B were prepared and were given to first collaborator that he was not aware about grouping. First Patient opened the first bag and the letter inside the bag (1) determined the patient group (A or B). Other patients in the two groups were subjected to the same procedure. Since drug and placebo had exactly similar package; the collaborator who delivered the required package to patients did know the sort of drug. Packaging and coding of administered medicine was carried out by research co-coordinator and none of patients or other researchers were aware of this grouping. Therefore the study was double blind. After taking the drug and follow up period, physical examination and patient`s information were collected by a collaborator that was unaware of the grouping and sort of intervention. N/A impacted teeth. Intervention 1: 2 Hours Before Surgery, intervention group were given a single dose of the oral combination drug brand Novafen that it is made in Alhavi factory(Acetaminophen (600 mg) + Ibuprofen (400 mg) + caffeine (15 mg)). Intervention 2: 2 Hours Before Surgery, control group were given a single dose of the oral Vitamin C (250 mg) that it is made in Darou Pakhsh factory.