IRCT20240507061694N1 IRCT 2026-07-02 Kashan University of Medical Sciences The effectiveness of evening primrose oil with misoprostol on cervical preparation before hysteroscopy and dilation and curettage Comparing the effect of evening primrose oil and misoprostol on cervical preparation before hysteroscopy and dilation and curettage 2026-07-23 anticipated 100 Recruiting https://irct.ir/trial/91255 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: -, Randomization description: Due to ease of use and saving time, the participants were divided into two groups using random sequence generation software. In this way, information such as the sample size and the number of groups is given to the software (Random allocation software) and the software provides a table of random numbers in which the letters A and B are randomly assigned to each number. In this study, numbers with letter A are in the intervention and numbers with letter B are in the control group, Blinding description: This study is a double-blind clinical trial in which the participant, the outcome assessor and the data analyst will be unaware of the treatment process. After randomization, the patients of each treatment group are introduced by researcher 1 (orology resident) to researcher 2 to evaluate the outcome. Researcher 2 ( the supervisor) is only an outcome assessor and records the results without knowing the type of treatment and its effects. A person who is an information analyst (statistician) also receives the recorded information at the end of the work and is not in the process of the intervention groups in any way. Drug injection will be done by an anesthesiologist. In each of the groups, the desired drugs is placed in the posterior fornix of the vagina by the resident 6 hours before hysteroscopy. The surgeon and the patients will not know the type of drug used, and before the surgeon enters, the removal of the probe and the drape will be done by another person, and if there is a vaginal pill, the pill will be removed so that the surgeon does not notice the presence of the vaginal pill and its type.Patients also do not know about the injectable substance. 2 Hysteroscopy and dilation and curettage. Intervention 1: Intervention group: Intervention group: In patients of this group, 1capsules of 100 mg evening primrose oil ( Abidi Pharmaceutical Company) are placed in the posterior fornix of the vagina by the resident, 6 hours before hysteroscopy. Intervention 2: Control group: Control group: In patients of this group, Suppository of 400 micrograms of misoprostol (Samisaz Pharmaceutical Company) are placed in the posterior fornix of the vagina by the resident, 6 hours before hysteroscopy. No - There is not a plan to make this available Justification or reason for not sharing IPD is -