IRCT20260622069921N1 IRCT 2026-06-28 CMH Hyderabad Effect of levothyroxine therapy on serum lipid profile in patients with subclinical hypothyroidism Changes in serum lipid profile following six months of levothyroxine therapy in patients with subclinical hypothyroidism: a quasi-experimental study 2025-03-26 anticipated 112 Complete https://irct.ir/trial/91093 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Treatment. 2-3 Sub-clinical hypothyroidism (SCH) refers to the condition in which there is increase in the levels of serum TSH with normal T3 and T4 levels. While the condition does not manifest clinically in majority of the cases, it is associated with weight gain, hormonal disturbances, insulin resistance, dyslipidemia, and increased incidence of cardiac complications.. Intervention group: All enrolled participants will receive levothyroxine sodium tablets (Thyroxine tablets - Getz Pharma) administered at an initial dose of 1.6 mcg/kg/day, based body weight taken once daily in the morning on an empty stomach, at least 30-60 mins before breakfast with water. Treatment will continue for six months. Compliance will be assessed during follow up visits.. No - There is not a plan to make this available Justification or reason for not sharing IPD is Limitations in participant consent, data sharing policy of institute and confidentiality of study participants.