IRCT20260621069896N1 IRCT 2026-06-23 yazd University The effect of resistance training combined with vitamin D supplementation on IGF-1 levels, neuromuscular function, and muscle strength in elderly women with sarcopenia The Effect of Resistance Training Combined with Vitamin D Supplementation on IGF-1 Levels and Neuromuscular Junction Function (Anti-Acetylcholine Receptor Antibody) in Elderly Women with Sarcopenia 2026-05-12 anticipated 40 Complete https://irct.ir/trial/91045 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Factorial, Purpose: Health service research, Other design features: This study is a quasi-experimental study with a pretest-posttest design and a control group and a 2x2 factorial design. The two intervention factors included “resistance training” (two levels: yes/no) and “vitamin D supplementation” (two levels: yes/no). Eligible participants were randomly assigned to four parallel groups (resistance training + vitamin D, resistance training alone, vitamin D alone, and control). The intervention duration was 8 weeks and the main objective was to evaluate the main effect of each intervention as well as the interaction effect (synergistic effect) between resistance training and vitamin D on IGF-1 levels, neuromuscular junction function, and muscle performance indices, Randomization description: After assessing the inclusion and exclusion criteria, eligible participants were randomly assigned to four groups (resistance training + vitamin D, resistance training, vitamin D, and control). The randomization method was block randomization with a block size of 4, which was performed using Excel software to maintain a balance in the number of individuals in each group. N/A Sarcopenia. Intervention group: Control group:Participants in this group did not receive any training intervention or supplementation and continued their daily activities.Intervention group 1 (resistance training with vitamin D supplementation):The intervention consisted of two concurrent parts:Resistance training: 8 weeks, 3 sessions per week (non-consecutive days), at an intensity of 60-75% of one repetition maximum (1RM), including 8 main movements (4 upper body movements and 4 lower body movements) in 3 sets of 10-12 repetitions with 1-2 minutes of rest between sets. Sessions were performed under the direct supervision of an exercise physiologist.Vitamin D supplementation: Oral intake of 50,000 IU of vitamin D3 (cholecalciferol) weekly for 8 weeks.Intervention group 2 (resistance training alone):Exactly the same resistance training protocol as group 1 (8 weeks, 3 sessions per week, 60-75% of 1RM, 8 movements, 3 sets of 10-12 repetitions) without receiving any supplementation.Third intervention group (vitamin D supplementation alone):Oral intake of 50,000 IU of vitamin D3 (cholecalciferol) weekly for 8 weeks, without performing a resistance training program.. No - There is not a plan to make this available Justification or reason for not sharing IPD is Due to the sensitive nature of personal health data of elderly participants and ethical considerations regarding privacy and confidentiality, there is no plan to share individual participant data.