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IRCT20260617069846N1 IRCT 2026-06-28 Mashhad University of Medical Sciences Evaluating the effects of peppermint and cumin extract on gastric residual volume and abdominal distension in mechanically ventilated patients Comparing the effects of mint and cuminum extract on residual volume and abdominal distention in patients under mechanical ventilation 2026-07-01 anticipated 114 Recruiting https://irct.ir/trial/90984 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: A random allocation sequence will be generated using randomization software. Allocation codes will be placed in sequentially numbered, opaque, sealed envelopes. After each eligible patient is enrolled, the next envelope in numerical order will be opened, and the patient will be assigned to one of the three study groups: peppermint, cumin, or control. 2 Under mechanical ventilated patients. Intervention 1: Intervention group1: Patients in this group will receive peppermint extract manufactured by Barij Essence Pharmaceutical Company. This product contains the main active constituents of peppermint, including menthol and menthone. This intervention will be administered as 20 drops of peppermint extract diluted in 30cc of drinking water via a NGT at 9, 15 ,21. The duration of the intervention will be 24 hours. Intervention group2: Patients in this group will receive Cuminum cyminum extract manufactured by Barij Essence Pharmaceutical Company. This product contains the main active constituents of cumin, including cuminaldehyde and other volatile compounds. This intervention will be administered as 20 drops of cumin extract diluted in 30cc of drinking water via a NGT at 9, 15 ,21. The duration of the intervention will be 24 hours. Intervention 2: Control group: Patient in this group will receive routine ward care and will not receive any herbal intervention. No - There is not a plan to make this available Justification or reason for not sharing IPD is Protection of Privacy
public Mahmood Bakhshi
Shahid Dr. Kharazmi Educational Complex, University Campus, East Gate of Ferdowsi University of Mashhad, Azadi Square.
Mashhad Iran (Islamic Republic of) 9137913199 +98 51 3884 6730 Bakhshim@mums.ac.ir Mashhad University of Medical Sciences scientific Mahmood Bakhshi
Shahid Dr. Kharazmi Educational Complex, University Campus, East Gate of Ferdowsi University of Mashhad, Azadi Square.
Mashhad Iran (Islamic Republic of) 9137913199 +98 51 3884 6730 Bakhshim@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) Be under mechanical ventilation Be aged 18years or older At least 24 hours have elapsed since admission Be hemodynamically stable Receiving enteral nutrition via NGT The patient or their legal representative provides informed consent 18 years no limit Both The patient has an allergy to peppermint or cumin The patient is pregnant or breastfeeding The patient has GI Bleeding or peptic ulcer disease The patient has gallstone or liver failure Z99.1 Dependence on respirator Treatment - Drugs Treatment - Drugs Intervention group1: Patients in this group will receive peppermint extract manufactured by Barij Essence Pharmaceutical Company. This product contains the main active constituents of peppermint, including menthol and menthone. This intervention will be administered as 20 drops of peppermint extract diluted in 30cc of drinking water via a NGT at 9, 15 ,21. The duration of the intervention will be 24 hours. Intervention group2: Patients in this group will receive Cuminum cyminum extract manufactured by Barij Essence Pharmaceutical Company. This product contains the main active constituents of cumin, including cuminaldehyde and other volatile compounds. This intervention will be administered as 20 drops of cumin extract diluted in 30cc of drinking water via a NGT at 9, 15 ,21. The duration of the intervention will be 24 hours. Control group: Patient in this group will receive routine ward care and will not receive any herbal intervention. Gastric residual volume. Timepoint: Measurements will be performed immediately before and 3 hours after gavage administration of the respective extract at12,18, and24 hours. Method of measurement: It will be measured using 50cc syringe. Abdominal distention. Timepoint: Measurements will be performed immediately before and 3 hours after gavage administration of the respective extract at12,18, and24 hours. Method of measurement: Measurements will be performed using measuring tape ( with an accuracy of 0.5 cm) before and 3 hours after gavage administration of the study extracts (at 12, 18,and 24). Mashhad University of Medical Sciences Approved 2026-06-02 Ethics committee of Mashhad University of Medical Sciences 4th Floor, Shahid Dr.Kharazmi Educational Complex, University Campus, Eastern Gate of Ferdowsi University of Mashhad, Azadi Square. Mashhad Razavi Khorasan Iran (Islamic Republic of)