IRCT20260609069717N1 IRCT 2026-09-22 Mashhad University of Medical Sciences The effect of Elaeagnus angustifolia cream on hemorrhoids during pregnancy The effect of Elaeagnus angustifolia cream on hemorrhoid symptoms in pregnant women 2026-10-07 anticipated 100 Recruiting https://irct.ir/trial/90733 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Participants will be randomly allocated to two groups using a randomized block design. The blockrand package will be employed through the website www.sealedenvelope.com. In the specified function, the number of treatment groups will be set to 2 and the block size to 4. The generated allocation sequence will be random with ablock size of four, and participants will be assigned to the intervention and control groups based on this sequence, Blinding description: This study is designed as a triple-blind randomized controlled trial. The researcher, participants, and statistician will be blinded to group allocation( intervention vs. control). An independent pharmacist( no involvement in sample allocation, intervention, or patient assessment) will be responsible for coding. Tubes containing the active cram and placebo will be labeled as A and B.The data provided to the statistician will be coded to ensure the group identity remains undisclosed. 3 Hemorrhoids in pregnancy. Intervention 1: Intervention group:Eligible pregnant women with hemorrhoid symptoms, confirmed as grade 1 or 2 by a physician at the health center, will receive lifestyle modification education and will apply 3 g of 5% oleaster extract cream (prepared at the Pharmacological Research Center for Medicinal Plants, Mashhad University of Medical Sciences) topically every 12 hours for 2 weeks. Intervention 2: Control group:Eligible pregnant women with hemorrhoid symptoms, confirmed as grade 1 or 2 by a physician at the health center, will receive lifestyle modification education and will apply 3 g of the base cream (without extract, prepared at the Pharmacological Research Center for Medicinal Plants, Mashhad University of Medical Sciences) topically every 12 hours for 2 weeks. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information is available