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IRCT20150706023084N30 IRCT 2026-05-19 Islamic Azad University Comparison of the effects of liraglutide and radio frequency cavitaion on abdominal obesityof the effects of liraglutide and radio frequency cavitaion on abdominal obesity liraCav tial A Randomized Clinical Trial Comparing the Efficacy of Liraglutide and Radiofrequency Cavitation in the Management of Abdominal Obesity. 2025-11-06 anticipated 64 Complete https://irct.ir/trial/89695 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Using Microsoft Excel software, random allocation of participants into study groups was performed. for this purpose, the random number generation function in Microsoft excel was used to assign a random decimal number between 0 and 1 to each participant. these random numbers were then sorted in ascending order, and based on their order, participants were allocated to the intervention and control groups.this randomization method was applied to minimize selection bias and to ensure homogeneity of baseline characteristics between the study groups, Blinding description: Due to the difference in the type of interventions (subcutaneous liraglutide injection versus radiofrequency cavitation therapy), complete blinding of participants and treating staff is not feasible. Therefore, the outcome assessor and data analyst will be blinded to the group allocation. The outcome evaluator (measuring weight, BMI, and waist circumference) and the statistical analyst will remain unaware of patient group assignments throughout the study. Accordingly, the trial is considered double-blind (evaluator- and analyst-blinded). 3 Obesity. Intervention 1: The intervention group consisted of 32 participants who underwent radiofrequency cavitation therapy over a period of 3 months. The treatment was performed at the Obesity and Physiotherapy Clinic of the Islamic Azad University of Medical Sciences and consisted of one 30-minute session per week applied to the abdominal region for the reduction of abdominal fat and central obesity.Radiofrequency cavitation is a noninvasive body contouring method that utilizes ultrasound waves and radiofrequency energy to reduce localized adipose tissue and improve skin tightness. At the end of the study, the investigated parameters measured at baseline and at the completion of the treatment period were compared. Intervention 2: Control group: liraglutide The control group consisted of 32 participants who received daily subcutaneous injections of liraglutide for a period of 3 months. The dosing regimen was administered as follows: 0.6 mg daily during the first week, 1.2 mg daily during the second week, 1.8 mg daily during the third week, 2.4 mg daily during the fourth week, and 3 mg daily from the fifth week until the end of the study, administered via subcutaneous injection. No - There is not a plan to make this available Justification or reason for not sharing IPD is no additional information is avaiable.
public ََAlireza Arefzade
Farhikhtegan hospital, opposite the Central Office of Islamic Azad University, end of North Sattari Street
Tehran Iran (Islamic Republic of) 1477899679 +98 21 4486 7262 Alireza.arefzadeh@iautmu.ac.ir Islamic Azad University scientific Alireza Arefzade
Farhikhtegan hospital, opposite the Central Office of Islamic Azad University, end of North Sattari Street
Tehran Iran (Islamic Republic of) 1477899679 +98 21 4486 7262 Alireza.arefzadeh@iautmu.ac.ir Islamic Azad University Iran (Islamic Republic of) All individuals without specific medical conditions, aged betweem 35 and 70 years Obese and have a body mass index(BMI) higher than 27 35 years 70 years Both Pregnancy Drug abuse Obesity due to specific endocrine disorders Alcohol use Specific diseases such as cancer E66.9 Obesity, unspecified Treatment - Devices Treatment - Drugs The intervention group consisted of 32 participants who underwent radiofrequency cavitation therapy over a period of 3 months. The treatment was performed at the Obesity and Physiotherapy Clinic of the Islamic Azad University of Medical Sciences and consisted of one 30-minute session per week applied to the abdominal region for the reduction of abdominal fat and central obesity.Radiofrequency cavitation is a noninvasive body contouring method that utilizes ultrasound waves and radiofrequency energy to reduce localized adipose tissue and improve skin tightness. At the end of the study, the investigated parameters measured at baseline and at the completion of the treatment period were compared Control group: liraglutide The control group consisted of 32 participants who received daily subcutaneous injections of liraglutide for a period of 3 months. The dosing regimen was administered as follows: 0.6 mg daily during the first week, 1.2 mg daily during the second week, 1.8 mg daily during the third week, 2.4 mg daily during the fourth week, and 3 mg daily from the fifth week until the end of the study, administered via subcutaneous injection. Abdominal measurement. Timepoint: Three months. Method of measurement: By measuring tape. Islamic Azad University Approved 2025-10-22 Ethics committee of Islamic Azad University of Medical Sciences Tehran faculty of medical sciences, Headquarters building of Islamic Azad university, Gholhak junction Amin Pabarja Street. Dr shariati st. Tehran Tehran Iran (Islamic Republic of)