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IRCT201112218488N1 IRCT 2013-05-10 Research Deputy of School of Medicine, Tehran University of Medical Sciences Comparison of the effects of oral and intravenous acetylcysteine ​​in treating acetaminophen poisoning Comparison of the effects of oral and intravenous acetylcysteine ​​in treating acetaminophen poisoning in admitted patients to poisoning emergency ward of Baharloo Hospital (2011-2012) 2012-01-01 anticipated 66 Complete https://irct.ir/trial/8953 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 3 Acetaminophen Poisoning. Intervention 1: Standard (20-hour intravenous NAC protocol is 150 mg/kg loading dose over 15 minutes, followed by an additional dose of 50 mg/kg over 4 hours, and then 100 mg/kg over 16 hours, for a total dose 300 mg/kg). Intervention 2: Experimental group (The 72-hour oral regimen is a 140-mg/kg loading dose followed by 70 mg/kg for 17 additional doses, for a total dose of 1330 mg/kg.
public Dr Hamed Pouraziz
Forensic Medicine Department, School of Medicine, Poursina Str
Tehran Iran (Islamic Republic of) +98 21 6640 5588 h-pouraziz@razi.tums.ac.ir Tehran University of Medical Sciences scientific Dr Hamed Pouraziz
Forensic Medicine Department, School of Medicine, Poursina Str
Tehran Iran (Islamic Republic of) +98 21 6640 5588 h-pouraziz@razi.tums.ac.ir Tehran University of Medical Sciences Iran (Islamic Republic of) Patients over 18 years old age which admitted to toxicological emergency ward of Baharloo hospital in Tehran which consume 7.5 gr acetaminophen during 24 hr ago will be conclude in the study. Inclusion Criteria: Patients over 18 years old age; consumption 7.5 gr acetaminophen during 24 hr before admittion Exclusion Criteria: Admission after 24 hr after consumption of acetaminophen; Co ingestion of cholinergic drugs; Primary unconsciousness; Primary hepatic encephalopathy; Presence of status epilepticus after NAC therapy; History of asthma and anaphylactiod reactions 18 years 99 years Both T39.8 Other nonopioid analgesics and antipyretics, not elsewhere classified Treatment - Drugs Treatment - Drugs Standard (20-hour intravenous NAC protocol is 150 mg/kg loading dose over 15 minutes, followed by an additional dose of 50 mg/kg over 4 hours, and then 100 mg/kg over 16 hours, for a total dose 300 mg/kg) Experimental group (The 72-hour oral regimen is a 140-mg/kg loading dose followed by 70 mg/kg for 17 additional doses, for a total dose of 1330 mg/kg. AST. Timepoint: First of the study and 72 hour after treatment. Method of measurement: Serum concentration. ALT. Timepoint: First of the study and 72 hour after treatment. Method of measurement: Serum concentration. Bilirubin. Timepoint: First of the study and 72 hour after treatment. Method of measurement: Serum concentration. Prothrombin time. Timepoint: First of the study and 72 hour after treatment. Method of measurement: Serum concentration. Treatment complication. Timepoint: At the first of the study up to 24 hour. Method of measurement: upon history and physical examination during treatment. Research Deputy of School of Medicine, Tehran University of Medical Sciences Approved 2012-02-26 Ethics committee in Research, Tehran University of Medical Sciences Ethics committee in Research, Vice chancellor of Research, Keshavarz Blv Tehran Iran (Islamic Republic of)