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IRCT20230111057111N2 IRCT 2026-04-20 Tehran University of Medical Sciences Studying the effect of two types of PRP injections in patients with plantar fasciitis Comparison of the Effectiveness of PRP Injection Using Peppering and Single-Point Methods in Patients with Plantar Fasciitis: a randomized clinical trial. 2026-04-30 anticipated 72 Recruiting https://irct.ir/trial/89499 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Other, Purpose: Treatment, Randomization description: Patients will be divided into two groups using a simple randomization method: - Group A: PRP injection with the peppering technique (3 small injections at points around the plantar fascia). - Group B: PRP injection with the single-point technique (one concentrated injection at the site of maximum pain and sensitivity), Blinding description: This study is designed as a single-blind study. Patients will not be aware of the type of injection technique (peppering or single-point). The injecting physician will inevitably be aware of the technique, but the clinical assessor (who will record VAS and FFI at subsequent visits) will be completely unaware of the group allocation of patients. N/A Plantar fasciitis/heel spur. Intervention 1: Intervention group: A:20 ml of blood is taken from the patient and PRP is prepared with a platelet concentration 4-6 times the baseline using a single-stage centrifuge and the standard Alpha kit. After obtaining informed consent, PRP is injected by palpation at the site of maximum tenderness. The injection is performed as a single dose in one session using the Peppering method (3 injections of 1 ml). Intervention 2: Intervention group: B: 20 ​​ml of blood is taken from the patient and PRP with a platelet concentration of 4-6 times the baseline is prepared using a single-stage centrifuge and the standard Alpha kit. After obtaining informed consent, PRP injection is performed by palpation at the site of maximum tenderness. Single-point method (one 3 ml injection) The injection is performed as a single dose in one session. Yes - There is a plan to make this available What will be shared: After deidentifying people, all the data obtained from the research, including the demographic information of the samples, clinical information and the results of the intervention can be shared. When: It is possible to access the results after nine to twelve months from the publication of the results. To whom: Researchers in academic centers and scientific research centers. Conditions: In order to data comparison in similar studies, the researchers of academic centers and scientific research centers have the possibility to receive data and re-analyze it if they comply with the principles of ethics in research. Where to obtain: Dr Amin Bakhshizadeh Imcheh with below email address:bakhshizadeh.dr@gmail.com and phone number:+989145339437 How to obtain: Researchers should send a written request to receive data to the relevant email address.A week after receiving an email , it will take action. Comments:
public Amin Bakhshizadeh Imcheh
Enghelab Square
tehran Iran (Islamic Republic of) 1417913191 +98 914 533 9437 bakhshizadeh.dr@gmail.com Tehran University of Medical Sciences scientific Amin Bakhshizadeh Imcheh
Enghelab square
tehran Iran (Islamic Republic of) 1417913191 +98 914 533 9437 bakhshizadeh.dr@gmail.com Tehran University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) Age 18-65 years, clinical diagnosis confirmed by a physician, failure to respond to conservative treatment, and ability to cooperate in the study 18 years 65 years Both History of surgery within the last year for plantar fasciitis, injection therapy, laser or shockwave therapy within the last 2 months, and use of Plavix within the last week Treatment - Other Treatment - Other Intervention group: A:20 ml of blood is taken from the patient and PRP is prepared with a platelet concentration 4-6 times the baseline using a single-stage centrifuge and the standard Alpha kit. After obtaining informed consent, PRP is injected by palpation at the site of maximum tenderness. The injection is performed as a single dose in one session using the Peppering method (3 injections of 1 ml). Intervention group: B: 20 ​​ml of blood is taken from the patient and PRP with a platelet concentration of 4-6 times the baseline is prepared using a single-stage centrifuge and the standard Alpha kit. After obtaining informed consent, PRP injection is performed by palpation at the site of maximum tenderness. Single-point method (one 3 ml injection) The injection is performed as a single dose in one session. Determination and comparison of the mean pain score (VAS) at 2 weeks and 12 weeks after injection in patients in intervention group A and intervention B-Determination and comparison of the foot functional status (FFI) score at 2 weeks and 12 weeks after injection in patients in intervention group A and intervention B-Determination and comparison of the incidence rate of various possible side effects after injection during follow-up in patients in intervention group A and intervention B-Determination and comparison of the mean pain score (VAS) and foot functional status (FFI) at the beginning of the study in patients in intervention group A and intervention B-Determination and comparison of the distribution of demographic and clinical characteristics at the beginning of the study in patients in intervention group A and intervention B. Timepoint: Change in mean pain intensity score based on the Visual Analogue Scale (VAS) from baseline (before injection) to 2 weeks and 12 weeks after PRP injection in the two peppering and single-point groups. Method of measurement: The Visual Analog Scale (VAS) will be used to assess the severity of patients' pain, and the Foot Function Index (FFI) questionnaire will be used to assess foot function. Scores for both instruments will be collected and recorded through direct patient questionnaires.Visual Analog Scale (VAS): This instrument is used to measure pain severity and is designed based on the Likert scale. In this scale, pain severity is reported as a number from 0 to 10, with 0 indicating complete absence of pain and 10 indicating the most severe pain imaginable.Foot Function Index (FFI): This questionnaire is used to assess the degree of foot dysfunction and consists of 17 questions categorized into three subscales: pain (5 questions), disability (9 questions), and mobility limitation (3 questions). Each question is scored numerically from 0 to 10. The final score for each subscale is calculated from the sum of the scores for its questions and determines the patient's level of pain, disability, and mobility limitation. Tehran University of Medical Sciences Approved 2025-12-25 Research Ethics Committee of Dr. Shariati Hospital Educational, Research and Treatment Center - Tehr Three ways of Jalal Al-Ahmad tehran Tehran Iran (Islamic Republic of)