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IRCT20260306068968N1 IRCT 2026-04-25 Tabriz University of Medical Sciences Evaluation of the effect of midazolam in controlling uncomplicated hypertension in patients presenting to the emergency department Evaluation of the effect of midazolam in controlling uncomplicated hypertension in patients presenting to the emergency department: a randomized, double-blind clinical trial study 2026-04-21 anticipated 142 Recruiting https://irct.ir/trial/89297 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: patients will divided with computer randomization (random Allocation Software version 1.0.0) to two blockes, which are discribed as case group (group with Midazolam and Captopril) and control Group (captopril), Blinding description: Blinding in this study will be designed as follows : Midazolam and placebo will be prepared in identical forms ( in similar numbered syringes ) by the principal investigator. To ensure allocation concealment, the sequentially numbered container method will be used.The medication containers will be pre-prepared and sequentially numbered in advance to prevent manipulation. The numbers will be assigned according to a computer-generated randomization program ( output file attached ) , from number 1 to 142. These will be provided swquentiallty , as needed , to the resident responsible for the thesis, and will be administered to patients according to the order of patient admission and enrollment in the emergency department. 2-3 Hypertension. Intervention 1: Intervention group:. Intervention 2: Control group:. Yes - There is a plan to make this available What will be shared: Data will be shared after being de-identified. When: Data will be uploaded after 6 months of publication. To whom: All researchers Conditions: Can be used in all research with citation of the source. Where to obtain: Accessible by email. How to obtain: Within one week of receiving the request Comments:
public asghar jafari rouhi
emergency department, Imam Reza Hospital, Gogasht street
Tabriz Iran (Islamic Republic of) 5166614756 +98 41 3335 2078 sadeghifatemeh0617@gmail.com Tabriz University of Medical Sciences scientific asghar Jafari Rouhi
emergency department, Imam Reza hospital, Golgasht street
Tabriz Iran (Islamic Republic of) 5166614756 +98 41 3335 2078 sadeghifatemeh0617@gmail.com Tabriz University of Medical Sciences Iran (Islamic Republic of) hypertension crisis contious 18 years no limit Both End organ damage Pregnant women 10 فشارخون Treatment - Drugs Treatment - Drugs Intervention group: Control group: Blood pressure control. Timepoint: At baseline, and at 15 , 30 , 45 , and 60 minutes after initation of treatment. Method of measurement: Blood pressure monitor. Patient satisfaction with the treatment. Timepoint: 15 - 30 - 45 - 60 minutes. Method of measurement: digital wristwatch for time measurement. Tabriz University of Medical Sciences Approved 2026-02-18 Tabriz university of medical sciences Golgasht street, Tabriz University of medical sciences Tabriz East Azarbaijan Iran (Islamic Republic of)