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IRCT20251218068375N1 IRCT 2026-02-17 Mazandaran University of Medical Sciences The Effect of Evening Primrose Oil on Cervical Ripening Comparison of the Effects of Evening Primrose Oil and Cervical Strip on Induction of Cervical Ripening and Birth Outcomes in Nulliparous Patients with Post-Term Pregnancies: A Clinical Trial Study 2026-03-21 anticipated 46 Complete https://irct.ir/trial/88902 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: The patient randomization list will be generated using the block balanced randomization method with the help of the website Randomization.com, specifically from the original generator section, using blocks of four. The generated list will then be placed sequentially into sealed envelopes. After preparing the sealed envelopes, the list will be destroyed. The researcher who generates the randomization list will have no involvement in the intervention process. Patients will be enrolled in the study according to the order of the randomization list and the contents of the envelopes, Blinding description: Outcome assessor (second midwife or blinded gynecologist): examination and recording of Bishop score and other clinical outcomes. 3 Childbirth. Intervention 1: Intervention group: Insertion of 500 mg vaginal capsules of evening primrose oil (Barij Essence Company, official packaging) by the researcher and evaluation for 5 days. Intervention 2: Control group: Cervical strip performed by a trained researcher every 48 hours. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no additional information
public Zahra Rahmani
no .233, Imam Khomeini Hospital, Razi Street
sari Iran (Islamic Republic of) ۳۳۱۳۱ -۴۸۱۶۶ +98 11 3335 0670 z.rahmani1972@gmail.com Mazandaran University of Medical Sciences scientific Zahra Rahmani
no .233, Imam Khomeini Hospital, Razi Street
sari Iran (Islamic Republic of) ۳۳۱۳۱ -۴۸۱۶۶ +98 11 3335 0670 z.rahmani1972@gmail.com Mazandaran University of Medical Sciences Iran (Islamic Republic of) Week 40 of pregnancy (from LMP or NT) First pregnancy Willingness to participate in the study Age over 18 years A healthy pregnant woman without underlying conditions. Women without contraindications for the use of evening primrose oil There is no contraindication for natural childbirth. Singleton pregnancy Normal fetal heart rate pattern, absence of uterine contractions, healthy fetal membranes. 18 years 40 years Female Rupture of fetal membranes during cervical preparation Causing potential side effects from the medication, such as headaches Individuals with a history of epilepsy Treatment - Drugs Treatment - Other Intervention group: Insertion of 500 mg vaginal capsules of evening primrose oil (Barij Essence Company, official packaging) by the researcher and evaluation for 5 days Control group: Cervical strip performed by a trained researcher every 48 hours Bishop score average. Timepoint: Once daily for a maximum of 5 consecutive days. Method of measurement: Vaginal examination and assessment of the Bishop score. Mazandaran University of Medical Sciences Approved 2025-11-26 Mazandaran University of Medical Sciences Ethics Committee No. 245, Mazandaran University of medical Sciences, Joibar Bolvar, Sari Sari Mazandaran Iran (Islamic Republic of)