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IRCT20201121049457N3 IRCT 2026-02-12 Mashhad University of Medical Sciences Comparison of pregnancy outcomes in 3- and 5-day frozen embryo transfer cycles with blastocysts in normoresponder women Comparison of pregnancy outcomes in 3- and 5-day frozen embryo transfer cycles with blastocysts in normoresponder women 2026-02-20 anticipated 148 Complete https://irct.ir/trial/88351 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Random assignment of eligible subjects to the study will be performed by an individual who is independent of the research team and has no involvement in the treatment process, participant follow-up, data collection, or recording. After the subjects have been identified as eligible for the study and their informed consent has been confirmed, they will be assigned to the study groups using a block randomization method (blocks of 4, 37 blocks). Randomization will be performed using a computerized random assignment sequence (https://www.sealedenvelope.com/), Blinding description: To conceal, cards are prepared that identify the intervention and control groups (for example, A on the card indicates the intervention group and B indicates the control group). Then these cards are placed in opaque envelopes, which are sorted and numbered according to the sequence generated by the software, and patients are assigned to the intervention or control group based on the card inside the envelope. With this concealment method, neither the patient nor the statistical consultant knows the type of treatment being received, and the statistical consultant, when analyzing the data, sees the type of treatment in coded form (A and B). N/A Infertility. Intervention 1: Intervention group: On the transfer day, a 5-day embryo is transferred. Intervention 2: Control group: On the transfer day, 3- and 5-day embryos are transferred. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No further information available
public Malihe Amirian
Milad Infertility Center - Imam Reza Hospital
Mashhad Iran (Islamic Republic of) 9137913316 +98 51 3854 3031 amirianm@mums.ac.ir Mashhad University of Medical Sciences scientific Malihe Amirian
Milad Infertility Center - Imam Reza Hospital
Mashad Iran (Islamic Republic of) 9137913316 +98 51 3854 3031 amirianm@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) Infertile women (18-41 years old) Normal uterine cavity Normal ovarian response to stimulation Women undergoing infertility treatment with IVF or microinjection and having at least 3 frozen embryos No history of endometriosis or endocrine disorders and no hysteroscopic surgery No severe male factor infertility No poor ovarian response (less than or equal to 3 oocytes) or excessive ovarian response (more than 20 oocytes) 18 years 41 years Female Cervical insufficiency Endometrial thickness less than 7 mm on the day of embryo transfer Unwillingness to continue the study N97 Female infertility Treatment - Other Treatment - Other Intervention group: On the transfer day, a 5-day embryo is transferred. Control group: On the transfer day, 3- and 5-day embryos are transferred. Chemical pregnancy rate. Timepoint: 2 week after embryo transfer. Method of measurement: BHCG serum. Clinical pregnancy rate. Timepoint: 6 weeks after embryo transfer. Method of measurement: Sonography. Abortion rate. Timepoint: Before 20 weeks of pregnancy. Method of measurement: Bleeding and expulsion of the fetus. Mashhad University of Medical Sciences Approved 2025-11-22 Ethics committee of Mashhad University of Medical Sciences Mashhad university of Medical Sciences Mashhad Razavi Khorasan Iran (Islamic Republic of)