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IRCT20251108067920N1 IRCT 2026-02-06 University of Isfahan Studying the effect of two exercise training methods on controlling obesity symptoms in women The Effect of a Resistance Training Program on Lipid Profile and the Expression of miRNA-126 and miRNA-221 in Women with Overweight/Obesity 2026-02-09 anticipated 30 Complete https://irct.ir/trial/87441 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: After obtaining the participants' consent and providing complete information about the intervention implementation process, 30 samples will be selected from among the eligible people. There will be 30 volunteers in this study. In the second step, the numbers 1 to 30 are inserted on the paper and placed in the lottery container. The 15 people who chose even numbers from the lottery are in the resistance training group and the people who chose odd numbers are in the aerobic training group. Blinding is not performed in this study. N/A Obesity. Intervention 1: Intervention group 1: Participants in this group will engage in specific aerobic exercises at the gym for a duration of 8 weeks, attending 3 sessions each week. The exercises will be conducted at an intensity level of 70-80% of the maximum heart rate for a total of 90 minutes. The aerobic activities will consist of running in the gym for 60 minutes. During the initial four weeks, the exercises will be performed at an intensity of 60-70% of the maximum heart rate, structured into 4 sets of 10 minutes each, with 5 minutes allocated for active rest in between. From the fifth to the eighth week, the intensity will increase to 80-70% of the maximum heart rate, with 6 sets of 10 minutes each and 3 minutes of active rest. The exercises will be tailored according to the participants' age and gender. The intensity will be adjusted every 4 weeks based on the participants' progress. Each session will commence with a 15-minute warm-up and conclude with a 5-10 minute cool-down that includes stretching and flexibility exercises. Intervention 2: Intervention Group 2: Participants in this group will engage in resistance training at an intensity of 70-80% of their one repetition maximum, performing 3 sets of 10-12 repetitions using exercise machines for 90 minutes, three times a week over a period of 8 weeks. During the initial sessions, their one repetition maximum will be assessed across various movements, and the first four weeks will commence with an intensity of 70-75% of the one repetition maximum. In the subsequent four weeks, following a new one repetition maximum test, the training will progress to 75-80% of the one repetition maximum based on individual progress. The resistance training regimen will encompass: leg curl and extension exercises, squats, chest presses, and overhead pull-down exercises using the machine. Each session will start with a 15-minute warm-up and conclude with a cool-down period of 5-10 minutes that includes stretching and flexibility exercises. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is The participants' data file will be accessible after obtaining permission from the university's Vice President for Research, and no decision has been made yet.
public Roya Hamdiasl
University St., University of Isfahan, Isfahan, Iran
Isfahan Iran (Islamic Republic of) 81746-73441 +98 31 4525 5260 royahmd221@gmail.com The University of Isfahan scientific Vazgen Minasian
University of Isfahan, University St., Isfahan, Iran
Isfahan Iran (Islamic Republic of) 81746-73441 +98 31 3627 8066 v.minasian@spr.ui.ac.ir The University of Isfahan Iran (Islamic Republic of) Lack of participation in regular physical activity during the past year Obesity (without other underlying diseases) Being in the age range of 25-40 years Having a body mass index of 26-35 25 years 40 years Female Having cardiovascular diseases Having musculoskeletal diseases E66.09 Other obesity due to excess calories Lifestyle Lifestyle Intervention group 1: Participants in this group will engage in specific aerobic exercises at the gym for a duration of 8 weeks, attending 3 sessions each week. The exercises will be conducted at an intensity level of 70-80% of the maximum heart rate for a total of 90 minutes. The aerobic activities will consist of running in the gym for 60 minutes. During the initial four weeks, the exercises will be performed at an intensity of 60-70% of the maximum heart rate, structured into 4 sets of 10 minutes each, with 5 minutes allocated for active rest in between. From the fifth to the eighth week, the intensity will increase to 80-70% of the maximum heart rate, with 6 sets of 10 minutes each and 3 minutes of active rest. The exercises will be tailored according to the participants' age and gender. The intensity will be adjusted every 4 weeks based on the participants' progress. Each session will commence with a 15-minute warm-up and conclude with a 5-10 minute cool-down that includes stretching and flexibility exercises. Intervention Group 2: Participants in this group will engage in resistance training at an intensity of 70-80% of their one repetition maximum, performing 3 sets of 10-12 repetitions using exercise machines for 90 minutes, three times a week over a period of 8 weeks. During the initial sessions, their one repetition maximum will be assessed across various movements, and the first four weeks will commence with an intensity of 70-75% of the one repetition maximum. In the subsequent four weeks, following a new one repetition maximum test, the training will progress to 75-80% of the one repetition maximum based on individual progress. The resistance training regimen will encompass: leg curl and extension exercises, squats, chest presses, and overhead pull-down exercises using the machine. Each session will start with a 15-minute warm-up and conclude with a cool-down period of 5-10 minutes that includes stretching and flexibility exercises. Cholesterol. Timepoint: Before intervention and after 8 weeks of exercise interventions. Method of measurement: Measurements are performed using special kits and the ELISA method. MiRNA-221. Timepoint: Before intervention and after 8 weeks of exercise interventions. Method of measurement: This procedure is conducted utilizing specialized kits and a real-time PCR apparatus. MiRNA-126. Timepoint: Before intervention and after 8 weeks of exercise interventions. Method of measurement: This procedure is conducted utilizing specialized kits and a real-time PCR apparatus. Cardiorespiratory Endurance. Timepoint: Before intervention and after 8 weeks of exercise interventions. Method of measurement: The cardiorespiratory endurance of the participants is assessed through the Rockport Walking/Running Test. Body fat Percentage. Timepoint: Before intervention and after 8 weeks of exercise interventions. Method of measurement: The body fat percentage of participants will be assessed through the use of hand calipers, skinfold measurements taken from multiple regions, and the application of the Peterson equation. Triglycerides. Timepoint: Before intervention and after 8 weeks of exercise interventions. Method of measurement: Measurements are performed using special kits and the ELISA method. Low Density Lipoprotein-Cholesterol. Timepoint: Before intervention and after 8 weeks of exercise interventions. Method of measurement: Measurements are performed using special kits and the ELISA method. High Density Lipoprotein-Cholesterol. Timepoint: Before intervention and after 8 weeks of exercise interventions. Method of measurement: Measurements are performed using special kits and the ELISA method. University of Isfahan Approved 2025-09-13 University of Isfahan Research Ethics Committee University of Isfahan, University St., Isfahan, Iran Isfahan Isfehan Iran (Islamic Republic of)