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IRCT20240108060648N2 IRCT 2025-11-14 The univercity of tabriz Effect of resistance and aerobic training on dynapenia and sarcopenia Effects of resistance and aerobic exercises training on CAF, CCR and P3NP related with sarcopenia and dynapenia in elderly 2025-11-15 anticipated 36 Complete https://irct.ir/trial/87401 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Factorial, Purpose: Prevention, Randomization description: The study population will be elderly women aged 65 to 75 years in Tabriz city, who will be selected on a convenience and voluntary basis. Then 36 people will be selected and after measuring body composition indices and morphological characteristics, they will be randomly divided into 3 groups control, aerobic and resistance groups using the Random allocation software program. Then the groups will be homogenized in terms of age and then concealment will be done using sealed envelopes to prevent bias, Blinding description: Concealment will be done using sealed envelopes to prevent bias. N/A Sarcopenia- Dinapenya. Intervention 1: first Intervention group: The aerobic exercise group will perform simple aerobic activities, walking, jogging, and slow running continuously in a figure-8 pattern. The load of walking sessions will gradually increase during the training weeks. Intervention 2: Second Intervention group: Resistance group exercises include movements that involve the main muscle groups. Each session will last about an hour, including 10 minutes of warm-up, 10 minutes of cool-down, and 40 minutes of main exercises. The movements will be performed stationary. In the first sessions, 8 movements will start in two rounds, and gradually the number of movements will increase to 10 movements in three rounds. Initially, movements will be performed for 10 to 15 repetitions, and as the sessions progress, they will reach 8 to 12 repetitions. The intensity of the movements will also range from 40 to 50 percent of 1RM (low intensity) to 60 to 80 percent of 1RM (moderate intensity). The exercises will initially start with low intensity, and then overload will be applied according to the readiness of the subjects. Intervention 3: Control group: The control group will follow their normal daily activities during this period. Subjects will be asked to refrain from exercise 48 hours before blood collection. Yes - There is a plan to make this available What will be shared: All data can be shared after being de-identified. When: Since 1405 To whom: It will be available to researchers working in academic and scientific institutions. Conditions: Researchers can use this data Where to obtain: Fatemeh Baharavar How to obtain: By email Comments:
public Fatemeh Baharavar
No77,babaei2,parvaz,tabriz,iran
Tabriz Iran (Islamic Republic of) 5164736931 +98 41 3386 2932 baharavar.F@tabrizu.ac.ir The univercity of tabriz scientific Fatemeh Baharavar
No77,babaei2,parvaz,tabriz,iran
Tabriz Iran (Islamic Republic of) 5164736931 +98 41 3386 2932 baharavar.F@tabrizu.ac.ir The univercity of tabriz Iran (Islamic Republic of) Possibility of doing sports activities The presence of sarcopenia 65 years 75 years Female Taking medication Having certain musculoskeletal diseases Underlying disease Presence of risk factors (chest pain, heart attack in first-degree relatives, limping when walking, etc.) Lifestyle Lifestyle Lifestyle first Intervention group: The aerobic exercise group will perform simple aerobic activities, walking, jogging, and slow running continuously in a figure-8 pattern. The load of walking sessions will gradually increase during the training weeks. Second Intervention group: Resistance group exercises include movements that involve the main muscle groups. Each session will last about an hour, including 10 minutes of warm-up, 10 minutes of cool-down, and 40 minutes of main exercises. The movements will be performed stationary. In the first sessions, 8 movements will start in two rounds, and gradually the number of movements will increase to 10 movements in three rounds. Initially, movements will be performed for 10 to 15 repetitions, and as the sessions progress, they will reach 8 to 12 repetitions. The intensity of the movements will also range from 40 to 50 percent of 1RM (low intensity) to 60 to 80 percent of 1RM (moderate intensity). The exercises will initially start with low intensity, and then overload will be applied according to the readiness of the subjects. Control group: The control group will follow their normal daily activities during this period. Subjects will be asked to refrain from exercise 48 hours before blood collection. Creatinine to cystatin C ratio. Timepoint: 24 hours before starting the training protocol and 48 hours after its completion. Method of measurement: Creatinine measurement using Pars Azmoun kits Tehran, Iran -Cys-C measurement using ELISA kit (BioVendor, Czech Republic). N-terminal propeptide of procollagen type 3. Timepoint: 24 hours before starting the training protocol and 48 hours after its completion. Method of measurement: N-terminal propeptide of procollagen type 3 kit from zellbio, Germany. Agrin C-terminal fragment. Timepoint: 24 hours before starting the training protocol and 48 hours after its completion. Method of measurement: Agrin C-terminal fragment kit from zellbio, Germany. Body composition index. Timepoint: 24 hours before the protocol and 48 hours after the protocol is completed. Method of measurement: Digital Arzoom scale for measuring the weight of subjects - German Seka model 769 height scale for measuring the height of tests - Body composition formula. Fatemeh Baharavar Approved 2025-05-24 Ethical committee of Tabriz University of Medical sciences Faculty of Physical Education and Sport Sciences, University of Tabriz, Abrassan street Tabriz East Azarbaijan Iran (Islamic Republic of)