IRCT20251101067848N1 IRCT 2025-11-11 Shahre-kord University of Medical Sciences Comparison of the effects of paroxetine and sertraline on pruritus Comparison of paroxetine and serteraline in pruritus in esrd patients under hemodialysis 2025-12-21 anticipated 62 Recruiting https://irct.ir/trial/87264 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: In this study, in order to allocate patients to two groups (First intervention and Second intervention), a randomization method using a random number table is used. Thus, a list of 62 patients eligible for the study is prepared and each patient is assigned a number from 1 to 62. Then, using a random number table, a random number is selected for each number. Odd numbers are assigned to First intervention group and even numbers to Second intervention group. 2 End Stage Renal Disease. Intervention 1: First intervention group: paroxetine 10 mg for the first week, 20 mg for the second, third and fourth weeks. Intervention 2: Second intervention group: sertraline 25 mg for the first week and 50 mg for the remaining three weeks. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is At this time, we have not made a definitive decision regarding the sharing of de-identified individual participant data. We will carefully evaluate these factors before determining whether and how the data can be shared.