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IRCT20250930067439N1 IRCT 2025-10-17 Mashhad University of Medical Sciences The effect of acupressure on the thirst of hemodialysis patients The effect of acupressure on the thirst of hemodialysis patients 2025-10-23 anticipated 90 Complete https://irct.ir/trial/86727 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Other, Randomization description: The present research is a single-blind randomized controlled clinical trial with a sham group. Considering a potential dropout rate of 10%, a total of 90 participants will be recruited through convenience sampling. Participants will then be randomly assigned into two groups—intervention and sham—with 45 participants in each group, using a block randomization method with a block size of four. The random allocation sequence will be generated using the “blockrand” package in the R statistical software. In this function, the number of treatments is set to two and the block size to four. The resulting random sequence will then be used to assign participants to the respective groups based on the generated four-block randomization scheme. To ensure allocation concealment, a sealed-envelope method will be applied. The random sequence will be written on small cards and placed inside sealed envelopes. Upon each participant’s enrollment in the study, one envelope will be opened, and the participant will be assigned to either the intervention or the sham group according to the code indicated on the card, Blinding description: Participants were unaware of whether acupressure was applied to true or sham points, and the data analyst was blinded to group allocation. N/A Chronic kidney disease. Intervention 1: Intervention group: participants who have acupressure applied to the LU-7, LI-4, KI-2, LR-2 points. Intervention 2: Control group: Participants in the sham group will have acupressure applied to SI-6, HT-7, BL-62, and GB-34 points. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no further information.
public Maryam Bagheri
Nursing and Midwifery School , Martyr Dr. Kharazmi Educational Building, University Campus, East Gate of Ferdowsi University of Mashhad, Azadi Square , Mashhad, Razavi Khorasan, Iran
Mashhad Iran (Islamic Republic of) 9177949025 +98 51 3884 6730 BagheriM@mums.ac.ir Mashhad University of Medical Sciences scientific Maryam Bagheri
Nursing and Midwifery School , Martyr Dr. Kharazmi Educational Building, University Campus, East Gate of Ferdowsi University of Mashhad, Azadi Square , Mashhad, Razavi Khorasan, Iran
Mashhad Iran (Islamic Republic of) 9177949025 +98 51 3884 6730 BagheriM@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) Participants aged between 18 and 65 years Written informed consent obtained prior to enrollment in the study Patients undergoing maintenance hemodialysis who have experienced symptoms of thirst during the past month Regular hemodialysis schedule, defined as three sessions per week No previous exposure to acupressure or other complementary therapies such as acupuncture Absence of any acute or chronic medical condition that may contraindicate the application of acupressure (e.g., advanced heart failure, soft tissue or vascular disorders of the limbs, or sensory–neurological impairments in the target areas) No active dermatological issues at the intended pressure sites, including wounds, inflammation, or rash No history of acupressure or acupuncture within the preceding three months Not currently taking medications known to affect salivation or thirst (e.g., tricyclic antidepressants, anticholinergics, antihistamines, or beta-blockers) No recent history of surgery or infection in the limbs Intact cognitive function, full consciousness, and the ability to understand and follow verbal instructions 18 years 65 years Both GB61 Chron Glomerular Filtration Rate (GFR) < 60 ml/min/1.73m² or presence of kidney damage that is present for more than 3 months. Evidence of kidney damage can include structural abnormalities (imaging or histology), albuminuria above normal limits, urinary sedime Other Other Intervention group: participants who have acupressure applied to the LU-7, LI-4, KI-2, LR-2 points. Control group: Participants in the sham group will have acupressure applied to SI-6, HT-7, BL-62, and GB-34 points. Thirst. Timepoint: Before the start of the intervention, the participants’ level of thirst will be assessed using two instruments: the Visual Analog Scale (VAS) and the Dialysis Thirst Inventory (DTI).In this study, acupressure will be applied in both the intervention and sham groups once daily (either in the morning or in the evening) for a duration of 2.5 minutes per point, over a period of four consecutive weeks.The researcher will evaluate the participants’ thirst level at the end of each dialysis session using the VAS, and at the end of each week using the DTI, in both the intervention and sham groups. Method of measurement: using two instruments: the Visual Analog Scale and the Dialysis Thirst Inventory. Mashhad University of Medical Sciences Approved 2025-09-30 Ethics committee of Mashhad University of Medical Sciences Nursing and Midwifery School , Martyr Dr. Kharazmi Educational Building, University Campus, East Gate of Ferdowsi University of Mashhad, Azadi Square , Mashhad, Razavi Khorasan, Iran Mashhad Razavi Khorasan Iran (Islamic Republic of)