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IRCT20251007067539N1 IRCT 2025-10-12 Zahedan University of Medical Sciences Evaluation of the Effect of Intravenous Methylprednisolone Injection on Sore Throat Caused by General Anesthesia Evaluation of the Effect of Intravenous Methylprednisolone Injection on Sore Throat Caused by General Anesthesia 2025-10-23 anticipated 100 Complete https://irct.ir/trial/86683 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients will be randomly assigned to either the intervention or control group using a block randomization method with an equal allocation ratio (1:1). The randomization sequence will be generated by computer software and kept confidential. To ensure allocation concealment, the sequences will be placed in opaque, sealed, and sequentially numbered envelopes. Each patient who meets the inclusion criteria will select one envelope in order of enrollment and, based on its contents, will be assigned to either the intervention group (receiving intravenous methylprednisolone) or the control group (receiving placebo), Blinding description: Patients will be randomly assigned to either the intervention or control group using a block randomization method with an equal allocation ratio (1:1). The randomization sequence will be generated by computer software and kept confidential. To ensure allocation concealment, the sequences will be placed in opaque, sealed, and sequentially numbered envelopes. Each patient who meets the inclusion criteria will select one envelope in order of enrollment and, based on its contents, will be assigned to either the intervention group (receiving intravenous methylprednisolone) or the control group (receiving placebo). 3 Sore throat from general anesthesia. Intervention 1: Intervention group: In the intervention group, prior to induction of anesthesia, patients will receive Methylprednisolone succinate (manufactured by Jaber Ibn Hayyan Pharmaceutical Company) at a dose of 3 mg/kg, infused intravenously over 10 minutes using a 10-mL syringe. Intervention 2: Control group: In the control group, 10 mL of normal saline will be infused intravenously over 10 minutes prior to induction of anesthesia. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is The study data are not yet ready.
public Sadaf jalili
Zahedan University of Medical Sciences, Dr. Hasabi Square, Zahedan
Zahedan Iran (Islamic Republic of) 9816743463 +98 992 841 5720 sadafjalili111@gmail.com Zahedan University of Medical Sciences scientific Sadaf jalili
Zahedan University of Medical Sciences, Dr. Hasabi Square, Zahedan
Zahedan Iran (Islamic Republic of) 9816743463 +98 992 841 5720 sadafjalili111@gmail.com Zahedan University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) The patient provides informed consent to participate in the study The patient's age is between 18 and 65 years. The patient has no known hypersensitivity to methylprednisolone. The patient has no underlying medical conditions The patient does not have any immunodeficiency disorders. 18 years 65 years Both Known drug hypersensitivity to methylprednisolone. Lack of patient cooperation during the study. History of chronic sore throat. Recent history of upper respiratory tract infection. History of osteoporosis. Multiple attempts at tracheal intubation. Treatment - Drugs Treatment - Drugs Intervention group: In the intervention group, prior to induction of anesthesia, patients will receive Methylprednisolone succinate (manufactured by Jaber Ibn Hayyan Pharmaceutical Company) at a dose of 3 mg/kg, infused intravenously over 10 minutes using a 10-mL syringe. Control group: In the control group, 10 mL of normal saline will be infused intravenously over 10 minutes prior to induction of anesthesia. Pain score. Timepoint: The Visual Analogue Scale(VAS) pain score will be recorded in both groups upon admission to the recovery room, 6 hours after extubation, and 24 hours after extubation. Method of measurement: Visual Analogue Scale. Zahedan University of Medical Sciences Approved 2025-10-05 Zahedan University of Medical Sciences Zahedan University of Medical Sciences, Dr. Hasabi Square Zahedan Sistan-va-Balouchestan Iran (Islamic Republic of)