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IRCT201505218104N12 IRCT 2017-08-20 Vice Chancellor of Research of Iran University of Medical Sciences Acute pain control with morphine suppository Analgesic effects of morphine suppository versus intravenous morphine in patients with extremity bone fracture: A placebo-controlled double-blind randomized clinical trial 2017-09-01 anticipated 224 Complete https://irct.ir/trial/8523 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Other design features: multi-center. 2-3 Pain in extrimity fracture. Intervention 1: Control group will receive intravenous morphine 5 mg and placebo suppository . Intervention 2: Case group will receive 10 mg suppository morphine and 5 ml of intravenous distilled water.
public Hoda Taghipour
Hemmat and Sheikh Fazlollah highways cross
Tehran Iran (Islamic Republic of) 1449614535 +98 21 8805 2963 negareirani1983@yahoo.com Iran University of Medical Sciences scientific Mohammad Amin Zare
Hemmat and Sheikh Fazlollah highways cross
Tehran Iran (Islamic Republic of) 1449614535 +98 21 8805 2963 mazare74@yahoo.com Iran University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) Inclusion Criteria: trauma patients with acute extremity fracture between 18 and 70 years old who have moderate to severe pain according to their visual analogue scale (VAS) score (score equal or higher than 5 of 10) Exclusion Criteria: known opioid allergy, a history of current/past drug abuse, other concurrent causes of pain (including trauma to other site), history of any chronic diseases (like respiratory, renal, hepatic, or heart failure), any conditions impairing the patient’s cooperation and participation in study (including altered consciousness, mental disorders and language barrier), pregnant and breastfeeding women and patients who had received analgesics 24 hours before admission 18 years 70 years Both XIX Injury, poisoning and certain other consequences of external causes Treatment - Drugs Treatment - Drugs Control group will receive intravenous morphine 5 mg and placebo suppository . Case group will receive 10 mg suppository morphine and 5 ml of intravenous distilled water. Severity of pain. Timepoint: 0.30.60 minutes and 1,3,6,12,18,24 hour. Method of measurement: numerical criteria on the base of VAS score. Apnea,decreased Oxygen suturation, decreased level of consciousness, decreased blood pressure, nausea and vomiting. Timepoint: 0-30-60 minutes and 1,3,6,12,18,24 hour. Method of measurement: Checking the patients respiratory rate, Oxygen saturation on pulse oximetry, checking blood pressure and asking about nausea and vomiting. Vice Chancellor of Research of Iran University of Medical Sciences Approved 2010-09-23 Ethics committee of Iran University of Medical Sciences Hemmat and Sheikh Fazlollah highways cross Tehran Iran (Islamic Republic of)