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IRCT201112258104N4 IRCT 2012-04-27 researching center of Tehran University of Medical Sciences Pain control in trauma patients Comparison of intravenous morphine with morphine plus low dose of ketamine in trauma patients with severe pain 2011-10-23 anticipated 200 Complete https://irct.ir/trial/8517 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. N/A trauma. Intervention 1: intervention group :administration of morphine 0.1 mg /kg +ketamine 0.2 mg/kg in minimum interval of 5 minutes with patient's request and evaluation of pain score and side effects in minutes 0;10;30;60;90;120 of study. Intervention 2: control group :administration of morphine 0.1 mg/kg +0.02 ml/kg of sterile water as placebo in minimum interval of 5 minutes with patient's request and evaluation of pain score and side effects in minutes 0;10;30;60;90;120 of study.
public Dr. Mohammad Amin Zare
Satarkhan st., Hazrat Rasool Hospital
Tehran Iran (Islamic Republic of) +98 21 6635 2022 mazare@sina.tums.ac.ir Tehran University of Medical Sciences scientific Dr. Saeed Abbasi
Satarkhan st., Hazrat Rasool Hospital
Tehran Iran (Islamic Republic of) +98 21 6635 2022 saieedabbasi@yahoo.com Tehran University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) Iran (Islamic Republic of) Inclusion criteria: patients above 18 years old with trauma only to limbs and severe pain (VAS equal or above 6). stable vital signs including systolic blood pressure equal or above 90 mm HG ; pulse rate between 60 and 120 per minute ; O2 saturation equal or above 90%; GCS =15 ; no addiction to drugs ;no consumption opioids or analgesics before begining of study ;no history of leaver diseases ;renal diseases; respiratory diseases ;cardiovascular diseases ; psychiatric diseases,blood diseases . Exclusion criteria: history of head trauma and contraindications for ketamine or morphine administration ; allergy to morphine or ketamine ; need to regional nerve block ; unable to conception of VAS;no interest to participate in study 18 years 50 years Both XIII musculoskeletal sysytem and connective tissue diseases Treatment - Drugs Treatment - Drugs intervention group :administration of morphine 0.1 mg /kg +ketamine 0.2 mg/kg in minimum interval of 5 minutes with patient's request and evaluation of pain score and side effects in minutes 0;10;30;60;90;120 of study. control group :administration of morphine 0.1 mg/kg +0.02 ml/kg of sterile water as placebo in minimum interval of 5 minutes with patient's request and evaluation of pain score and side effects in minutes 0;10;30;60;90;120 of study Pain control. Timepoint: 0, 10, 30, 60, 90 and 120 minutes after treatment. Method of measurement: Visual Analogous Scale (VAS). Side effects and changes in vital signs. Timepoint: 30 and 60 minutes after treatment. Method of measurement: Patient monitoring. researching center of Tehran University of Medical Sciences Approved 2010-08-20 Ttehran University of Medical Sciences Ethics Committee Ghods street- Keshavarz blvd- Tehran Tehran Iran (Islamic Republic of)