IRCT20250603066044N1 IRCT 2025-07-13 Ahvaz University of Medical Sciences The effect of hibiscus flower extract on blood pressure. Evaluation the effect of Althaea officinalis extract oral solution on blood pressure levels in patients with high blood pressure (HTN): A randomized double blind clinical trial 2025-06-21 anticipated 70 Complete https://irct.ir/trial/84065 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: The permutation block randomization method is used. Blocking is usually used to balance the number of samples allocated to each of the study groups. This feature helps researchers to ensure that the number of samples allocated to each of the study groups is equal in cases where interim analyses are needed during the sampling process. In this two-group clinical trial, the block size is 4. The allocation ratio between the two groups is 1:1. The randomization tool is the blockrand package of R software. For concealment, we use random allocation concealment. This method is used to perform random sequence on participants in such a way that the assigned group is not known before the individual is assigned. Using sealed opaque envelopes with a random sequence, in which each of the random sequences created is recorded on a card and the cards are placed inside the envelopes in order. In order to maintain the random sequence, the outer surface of the envelopes is numbered in the same order. Finally, the envelopes are sealed and placed in a box in order. When participant registration begins, based on the order of entry into the study, one of the envelopes is opened in order and the assigned group of that participant is revealed, Blinding description: To control the entry criteria for the study, the initial visit will be conducted by a physician. Coded medications will be prepared and delivered to the study assistant, who will not be informed about the types of medications. The codes will be sent separately in sealed envelopes so that neither the researcher nor the patient will be aware of the contents of the medication container until the end of the study. The medications will be administered to the patients by the study assistant using a random block method. Patients will be divided into two groups (35 individuals in each group) using a randomization list prepared by a statistical consultant. 3 Essential (primary) hypertension. Intervention 1: Intervention group: Intervention group: In addition to antihypertensive medications, an oral solution of hibiscus extract prepared by Zarband Pharmaceutical Company will be administered twice daily for 2 weeks, with each dose being 10 milliliters. Intervention 2: Control group: Placebo: In addition to antihypertensive drugs, a carrier solution containing an oral extract of hibiscus flower without active ingredients, prepared at the Faculty of Pharmacy in Ahvaz, will be administered for 2 weeks, twice a day, with each dose being 10 milliliters. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is In this regard, permission must be obtained from the patients and consultation should be made with the project colleague