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IRCT138803211548N5 IRCT 2010-02-20 Deputy for Research of Shiraz University of Medical Sciences To compare The effect of taking aspirin and placebo in two different diurnal times (morning and night) on mean of 24 hours blood pressure in women who are at preeclampsia risk The effect of taking aspirin in two different diurnal times (morning and night) on mean of 24 hours blood pressure in women who are at preeclampsia risk 2008-04-12 anticipated 64 Complete https://irct.ir/trial/835 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention. 3 Preeclampsia. Intervention 1: testing group 1: aspirin (100mg) at awakening, 1 pill per day. Intervention 2: testing group 2: aspirin (100mg) at bed time, 1 pill per day. Intervention 3: control group 1: placebo at awakening, 1 pill per day. Intervention 4: control group 2: placebo at bed time, 1 pill per day.
public
scientific Dr. Amoee
Hafez hospital, Abivardi
Shiraz Iran (Islamic Republic of) +98 71 1627 1531 abdalikh@sums.ac.ir Iran (Islamic Republic of) Inclusion criteria: women with personal and family history of gestational hypertension and preeclampsia, history of spontaneous abortion, obesity, adolescent or middle age nulliporous pregnancy (less than 18 or more than 35 years). Exclusion criteria: using steroidal , non steroidal or antihypertensive drugs, multiple pregnancy, cardiovascular disease, chronic gastroenteritis and adrenal disease, asthma, hemorrhage disease, diabetes or any other endocrine disease ,hyperthyroidism, hematological disease ,intolerance to devise ,Ambulatory blood pressure monitoring. 17 years 42 years Female 010 Pre-existing hypertension complicating pregnancy, childbirth and the puerperium Prevention Prevention Prevention Prevention testing group 1: aspirin (100mg) at awakening, 1 pill per day testing group 2: aspirin (100mg) at bed time, 1 pill per day control group 1: placebo at awakening, 1 pill per day control group 2: placebo at bed time, 1 pill per day 24 hours mean of blood pressure. Timepoint: 7 times, every month from the day of recruitment. Method of measurement: 24 hour Blood pressure monitoring automatic device. Preeclampsia prevention and decrease fetal and maternal complications. Timepoint: during and at the end of the pregnancy. Method of measurement: clinically and sonography approved by specialist. Deputy for Research of Shiraz University of Medical Sciences Approved 2008-09-10 Ethical committee of Shiraz University of medical sciences Namazi squer Shiraz Iran (Islamic Republic of)