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IRCT20241225064163N2 IRCT 2025-05-17 Mashhad University of Medical Sciences The effect of ointment containing Green Tea extract and Peganum harmala in the treatment of Genital Warts in Women Investigating the effect of ointment containing Green Tea extract and Peganum harmala in the treatment of Genital Warts in Women: a controlled randomized clinical trial 2025-05-20 anticipated 60 Complete https://irct.ir/trial/83451 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: In this study, the Block Randomization method (with blocks of 4) will be used. For this purpose, the website https://www.sealedenvelope.com/ will be utilized, Blinding description: For blinding purposes, the gels will be made to look similar in color and appearance to the tubes and provided to the researcher. Each tube has three different codes, which are known only to the pharmacist. 1-2 Genital warts. Intervention 1: Intervention group 1: gel containing green tea extract and pecan seeds in a 50-50 ratio. Intervention 2: Control group: gel containing green tea extract. Intervention 3: Intervention group 2: gel containing green tea extract and pecan seeds in a 80-20 ratio. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information
public Davoud Salarbashi
Gonabad Medical Sciences Central Headquarters, Imam Khomeini Street, Ghadir Square, Gonabad
Gonabad Iran (Islamic Republic of) 9919991766 +98 915 303 0852 davoud.salarbashi2@gmail.com Gonabad University of Medical Sciences scientific Davoud Salarbashi
Gonabad Medical Sciences Central Headquarters, Imam Khomeini Street, Ghadir Square, Gonabad
Gonabad Iran (Islamic Republic of) 9919991766 +98 915 303 0852 davoud.salarbashi2@gmail.com Gonabad University of Medical Sciences Iran (Islamic Republic of) The individual must not have any specific medical illnesses. They should have no other sexually transmitted diseases (STDs) In the past 6 months, they should not have been under psychiatric supervision and should not be taking psychiatric medications. They must not be allergic to green tea or pennyroyal seeds They should not have speech or behavioral disorders that hinder communication with the researcher. They must not have genital warts inside the vagina Genital warts should be limited to the skin. The number of lesions should be between 2 and 30 The surface area of lesions should be between 2 and 600 square millimeters Their spouse should not have genital warts They should have no history of using specific medications. Both they and their spouse should have only one sexual partner. 18 years 50 years Female They are breastfeeding or pregnant. They are smoker They are infected with other STDs A63.0 Anogenital (venereal) warts Treatment - Drugs Treatment - Drugs Treatment - Drugs Intervention group 1: gel containing green tea extract and pecan seeds in a 50-50 ratio Control group: gel containing green tea extract Intervention group 2: gel containing green tea extract and pecan seeds in a 80-20 ratio Number and size of external genital wart lesions. Timepoint: Every two weeks until the 10th week. Method of measurement: The patient is examined by the researcher and all areas of the genital area such as the posterior foreskin, labia majora, groin, pubic and anal areas, and perianal are examined for the presence of lesions and the number and size of the lesions are recorded. To determine the initial size of the lesion, the two main perpendicular diameters of each lesion are measured in millimeters with a ruler and the area of ​​each lesion is obtained from the product of these two diameters. Occurrence of new lesions. Timepoint: Every two weeks. Method of measurement: Observation. Occurrence of reactions and side effects. Timepoint: Every two weeks. Method of measurement: Questioning the patient. Mashhad University of Medical Sciences Approved 2025-04-21 Ethics Committee of Mashhad University of Medical Sciences Ahmad Abad Street Mashhad Razavi Khorasan Iran (Islamic Republic of)