IRCT201110247882N1 IRCT 2012-11-27 Hormozgan University of Medical Sciences(HUMS) Honey effect on cough alleviation Comparison Study of Honey versus Diphenhydramine Effect on Cough Alleviation in 2-5 Years Old Children with Viral Upper Respiratory Tract Infection 2010-09-23 anticipated 126 Complete https://irct.ir/trial/8317 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive. N/A Common Cold. Intervention 1: Diphenhydramin syrup, 5mg/kg/TDS,for 48 h. Intervention 2: Honey with the same volume and frequency and duration of use with diphenhydramine.

public Dr. Mahshid Ahmadi

Gamero building, Soltan tooye st, Velayat st, Saade Salman Sq

Sari Iran (Islamic Republic of) 4818914799 +98 15 1320 7026 mshahmadi@yahoo.com Mazandaran University of Medical Sciences scientific Dr. Mahshid Ahmadi

Gameron building, Soltan Tooye st, Velayat st, Saade Salman Sq

Sari Iran (Islamic Republic of) 4818914799 +98 15 1320 7026 mshahmadi@yahoo.com Mazandaran University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria:The patients's age is two to five years old; Acute cough is the chief complaint;The symptoms of viral upper respiratory tract infection are the only concomitant symptoms [fever (oral temperature from 37.8to 38.5 or axillary temp from 37.2 to 37.9) rhinorrhea , sneezing, blocked nose, sore throat, cough, mild headache, restlessness, hoarseness];The patient has been brought to clinic at first or second day of begining cough;The patient has not bacterial infections symptoms of upper respiratory tract (moderate to high fever, sever sore throat with painful swallowing, severe headache, nausea, vomiting, abdominal pain, ...);The patient has not the symptoms of lower respiratory tract infection (high fever, chills, dyspnea, malaise, pleuritic chest pain, tachypnea, retraction); There are not associated infections such as otitis and sinusitis; Allergy is not considered ( associated symptoms such as itchy eye & nose, history of repeating similar symptoms, a history of prolonged cold periods, positive family history; The patient has not signs of Reactive Airway Disease (wheezing, shortness of breath,pressure or tightness feeling in chest , tachypnea, tachycardia); The parents have not begun any drug before coming to clinic . Exclusion criteria were: Onset of otitis or sinusitis symptoms; Onset of symptoms of lower respiratory tract involvement; Adding a bacterial infection, (purulent nasal discharge, high fever, difficulty breathing, Periorbital edema, facial pain); Not using of recommended treatments; Adding other drugs to recommended treatment; Non-coordinated reports of persons who take care of patients. 2 years 5 years Both J00 Acute nasopharyngitis Treatment - Drugs Treatment - Drugs Diphenhydramin syrup, 5mg/kg/TDS,for 48 h Honey with the same volume and frequency and duration of use with diphenhydramine Number of Night cough. Timepoint: Before intervention, 48 h after intervention. Method of measurement: Visual scale of the number of coughs. Severity of night cough. Timepoint: Before intervention, 48 h after intervention. Method of measurement: Visual scale of severity of coughs. The number of daily cough. Timepoint: Before intervention, 48 h after intervention. Method of measurement: Visual scale of the number of coughs. Severity of daily cough. Timepoint: Before intervention, 48 h after intervention. Method of measurement: Visual scale of severity of cough. Hormozgan University of Medical Sciences(HUMS) Approved 2012-07-29 Hormozgan university of Medical Sciences Ostandari Blv Bandar Abbas Iran (Islamic Republic of)