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IRCT20250304064931N1 IRCT 2025-05-29 Khyber Medical University Peshawar Comparison of the Effectiveness of EEG-Based Neurofeedback Therapy Versus Conventional Therapies (Medication and Mindfulness-Based Cognitive Behavioral Therapy) in Improving Symptoms of Obsessive-Compulsive Disorder Patients Comparison of the Effectiveness of EEG-Based Neurofeedback Therapy Versus Conventional Therapies (Medication and Mindfulness-Based Cognitive Behavioral Therapy) in Improving Symptoms of Obsessive-Compulsive Disorder Patients: A Randomized Controlled Trial 2025-04-28 anticipated 80 Complete https://irct.ir/trial/83149 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: Randomized controlled trial (RCT) design, Randomization description: To implement random allocation, we will use OpenEpi software to generate a list of random numbers corresponding to participant IDs. Each eligible participant will be assigned a unique identifier, and based on the random number sequence, they will be allocated to either the intervention or control group in a 1:1 ratio. Allocation will be performed using a simple randomization approach without stratification or blocking. The randomization list will be prepared in advance by an independent statistician not involved in participant recruitment to maintain allocation concealment. The group assignments will be placed in sequentially numbered, opaque, sealed envelopes, which will be opened only after participant enrollment. N/A Obsessive-Compulsive Disorder (OCD) is a chronic mental health condition characterized by persistent, intrusive thoughts (obsessions) and repetitive behaviors or mental acts (compulsions) that an individual feels compelled to perform. These symptoms can cause significant distress, interfere with daily functioning, and diminish quality of life. The study focused on understanding the clinical presentation, underlying mechanisms, and potential interventions for individuals affected by OCD. Emphasis was placed on early diagnosis, treatment outcomes, and the socio-cultural context influencing symptom expression and treatment adherence.. Intervention 1: Control group: Group A (treatment as usual). Intervention 2: Intervention group: Group B (mindfulness based cognitive therapy with medication). Intervention 3: Intervention group: roup C (electroencephalogram based neurofeedback with medication). Intervention 4: Intervention group: Group D (Mindfulness based cognitive therapy/Electroencephalogram based neurofeedback without medication). Yes - There is a plan to make this available What will be shared: I will provide study protocols, data analysis, and codes When: After the completion of my thesis, I will provide for a long time. To whom: To IRCT and other members Conditions: For research and educational purposes Where to obtain: from websites and journals How to obtain: online Comments: N/A
public Sumaira Mehreen
Department of Psychology, university of Peshawar, Khyber Pakhtunkhwa, Peshawar
Peshawar Pakistan 25000 +92 345 9093113 sumaira.mehreen@lrh.edu.pk University of Peshawar scientific Sumaira Mehreen
Department of Psychology, university of Peshawar, Khyber Pakhtunkhwa, Peshawar
Peshawar Pakistan 25000 +92 91 9211430 sumaira.mehreen@lrh.edu.pk University of Peshawar Pakistan Diagnosed with Obsessive-Compulsive Disorder (OCD) according to DSM-5 criteria. Aged between 18 and 40 years. No neurological disorder (stroke, head injury, epilepsy, dementia). No severe medical conditions (e.g., hepatic failure, renal failure). No history of psycho-surgery or neurosurgical procedures. 18 years 40 years Both Psychiatric comorbidity (schizophrenia, psychosis, delusional disorders). Substance abuse or drug dependence. F42 Obsessive-compulsive disorder Treatment - Drugs Treatment - Other Treatment - Other Treatment - Other Control group: Group A (treatment as usual) Intervention group: Group B (mindfulness based cognitive therapy with medication) Intervention group: roup C (electroencephalogram based neurofeedback with medication) Intervention group: Group D (Mindfulness based cognitive therapy/Electroencephalogram based neurofeedback without medication) Obsessive compulsive disorder. Timepoint: Before intervention (baseline), and on every follow up (monthly in group A for 3 months which is treatment as usual group, and weekly in treatment group B, C and D for 12weeks. Method of measurement: Yale brown obsessive compulsive scale (YBOCS). Lady Reading Hospital Peshawar N/A N/A Approved 2024-01-14 Institutional Review Board- Lady Reading Hospital Peshawar Soekarno Rd, Pipal Mandi, Peshawar, 25000 Peshawar Khyber Pakhtunkhwa Pakistan