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IRCT20250415065336N1 IRCT 2025-10-08 Kharazmi University Effect of dual training on cathepsin B and mayostatin The effect of dual-task (Cognitive-Functional) training on the biomarkers Cathepsin B and Myostatin in elderly individuals 2025-07-11 anticipated 20 Complete https://irct.ir/trial/82963 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive, Other design features: This study in the field of sports and health aims to examine the effects of a dual-task (physical-cognitive) training program on cognitive and physical performance in elderly participants, Randomization description: Randomization was performed using block stratified randomization based on age (60–74 and ≥75 years) at the individual level. The random sequence was generated in blocks of four with a 1:1 ratio by an independent statistician using random number software. Allocation concealment was ensured with sequentially numbered, opaque, sealed envelopes (SNOSE), Blinding description: The examiner will be an experienced individual external to the research team, and only the data (with groups labeled as 1 and 2) will be provided to the statistical analyst. Thus, both individuals remain blinded to the study results. N/A Elderly. Intervention 1: Intervention group: Participants: 12 individuals (male/female) /"Participants will complete an 8-week dual-task (functional-cognitive) training program consisting of:• Frequency: 2 sessions/week• Duration: 30-50 minutes/session / Component : Functional training: Aerobic, resistance, and balance exercises / Cognitive tasks: Memory recall and arithmetic exercises / Training load will be progressively modified through: Increased session duration Greater movement repetitions / Exercise intensity will be monitored using the Borg RPE scale:• Weeks 1-2: Moderate intensity (RPE 8-10)• Subsequent weeks: Vigorous intensity (RPE 10-14). Intervention 2: Control group :12 participants (male/female) / Control participants will be asked to maintain their normal lifestyle patterns and will not participate in structured exercise. They will complete pre-test and post-tests at the same time as the intervention group. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no further information
public Fatemeh Sadat Zendepour
Faculty of Physical Education, Hesari Street, Hassani Square, Mirdamad Boulevard
Tehran Iran (Islamic Republic of) 3311115447 +98 21 2222 8001 fatemehzendehpour@gmail.com Kharazmi University scientific Sadegh Amani Shalmazari
Faculty of Physical Education, Hesari Street, Hassani Square, Mirdamad Boulevard
Tehran Iran (Islamic Republic of) 3311115447 +98 21 2222 8001 amani_sadegh@khu.ac.ir Kharazmi University Iran (Islamic Republic of) Age 60–80 years No participation in exercise training or physiotherapy during the intervention No use of specific sports or medicinal supplements No history of acute chronic cardiovascular or metabolic diseases No open surgery in the past 6 months to 1 year 60 years 80 years Both Participant's unwillingness or lack of interest to continue in the study Physician's recommendation for withdrawal from the study Non-participation in 3 consecutive training sessions Non-participation in the post-test Rehabilitation Rehabilitation Intervention group: Participants: 12 individuals (male/female) /"Participants will complete an 8-week dual-task (functional-cognitive) training program consisting of:• Frequency: 2 sessions/week• Duration: 30-50 minutes/session / Component : Functional training: Aerobic, resistance, and balance exercises / Cognitive tasks: Memory recall and arithmetic exercises / Training load will be progressively modified through: Increased session duration Greater movement repetitions / Exercise intensity will be monitored using the Borg RPE scale:• Weeks 1-2: Moderate intensity (RPE 8-10)• Subsequent weeks: Vigorous intensity (RPE 10-14). Control group :12 participants (male/female) / Control participants will be asked to maintain their normal lifestyle patterns and will not participate in structured exercise. They will complete pre-test and post-tests at the same time as the intervention group. Serum Cathepsin B level. Timepoint: Pre and Post- Test (48 hours before and after 8 weeks of dual training). Method of measurement: Abcam Human Cathepsin B ELISA Kit. Myostatin level. Timepoint: Pre and Post-test. Method of measurement: ELYZA kit. Cognitive performance. Timepoint: Pre and Post-test (72 hours before and after 8 weeks of dual training). Method of measurement: Stroop test. Functional-cognitive test. Timepoint: Pre and Post-test (72 hours before and after 8 weeks of dual training. Method of measurement: Timed Up and Go test. Aerobic fitness. Timepoint: Pre and Post-test (72 hours before and after 8 weeks of dual training. Method of measurement: 6-minute walk test. Fat profile. Timepoint: Pre and Post-test (48 hours before and after 8 weeks of dual training. Method of measurement: Elyza kit. Kharazmi University Approved 2024-05-05 "The Research Ethics Committee of Kharazmi University" Kharazmi University No.43 South Mofateh St Tehran, 15719-14911 Iran Tehran Tehran Iran (Islamic Republic of)