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IRCT20250330065181N1 IRCT 2025-06-17 Oroumia University of Medical Sciences Comparing the effectiveness of using BiPAP and CPAP for successful weaning from the ventilator in children with underlying neurological problems admitted to the PICU (CPAP)Bilevel Positive Airway Pressure(BiPAP), Continuous Positive Airway Pressur Comparing the effectiveness of using BiPAP and CPAP for successful weaning from the ventilator in children with underlying neurological problems admitted to the PICU 2025-03-21 anticipated 24 Complete https://irct.ir/trial/82686 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization will be performed using Random Number Generation software. Random generator is a simple software for generating random numbers between two specified numbers, where the discrete numbers are from 1 to 24 and each patient is identified by a number. First, the software randomly selects 12 numbers from 1 to 24, which are assigned to 12 intubated patients with underlying neurological problems and will be placed on BiPAP. The remaining 12 numbers from 1 to 24 will be assigned to other intubated patients with neurological problems and will be placed on CPAP. Now, patients are assigned numbers one to 24 in order of admission and are put on BiPAP or CPAP. For example, initially according to the software, we have 12 numbers that are supposed to be put on BiPAP, for example, numbers 3,4,7,11,13,14,... Now, the first patient with the entry criteria will be number one and will be put on CPAP. The next patient is assigned number 2 and is put on CPAP. The next patient is assigned number 3 and is put on BiPAP, and so on, up to 24 patients. N/A Neurological diseases. Intervention 1: Control group: 12 intubated patients with underlying neurological disease, who were randomly selected, were weaned from the ventilator after meeting the conditions and immediately underwent Continuous Positive Airway Pressure(CPAP), respiratory assistance, using an anatomical face mask and were monitored for 72 hours for the need for re-intubation. Intervention 2: Intervention group: 12 Intubated patients with underlying neurological disease, who were randomly selected, were weaned from the ventilator after meeting the conditions and immediately underwent Bilevel Positive Airway Pressure(BiPAP), respiratory assistance, using an anatomical face mask and were monitored for 72 hours for the need for re-intubation. Yes - There is a plan to make this available What will be shared: Successful extubation rate When: 1 Mon To whom: Mohammad Salavatizade, Mohammad Valizade, Babak Hasanlooyi, Tohid Ebadi Conditions: After statistical analysis Where to obtain: Tohid Ebadi How to obtain: Email Comments:
public Tohid Ebadi
Borujerdi
Urmia Iran (Islamic Republic of) 5713147454 +98 44 3657 2318 Tohid2ebadi@gmail.com Oroumia University of Medical Sciences scientific Tohid Ebadi
Borujerdi
Urmia Iran (Islamic Republic of) 5713147454 +98 44 3657 2318 Tohid2ebadi@gmail.com Oroumia University of Medical Sciences Iran (Islamic Republic of) Children with underlying neurological disease. Children who are intubated. 1 month 18 years Both Children with other underlying diseases such as heart disease. G80 Cerebral palsy Treatment - Other Treatment - Other Control group: 12 intubated patients with underlying neurological disease, who were randomly selected, were weaned from the ventilator after meeting the conditions and immediately underwent Continuous Positive Airway Pressure(CPAP), respiratory assistance, using an anatomical face mask and were monitored for 72 hours for the need for re-intubation. Intervention group: 12 Intubated patients with underlying neurological disease, who were randomly selected, were weaned from the ventilator after meeting the conditions and immediately underwent Bilevel Positive Airway Pressure(BiPAP), respiratory assistance, using an anatomical face mask and were monitored for 72 hours for the need for re-intubation. Successful extubation. Timepoint: 72 hours after extubation. Method of measurement: Information collection form. Complications of intubation. Timepoint: 72 hours after extubation. Method of measurement: Information collection form. Oroumia University of Medical Sciences Approved 2024-12-21 Urmia University of Medical Sciences Ethics Committee No 11, Borujerdi Street Urmia West Azarbaijan Iran (Islamic Republic of)