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IRCT20230907059376N7 IRCT 2025-03-24 Khyber Medical University, Peshawar Effects of Proprioceptive neuromuscular facilitation stretching vs joint mobilization for improving joint mobility and quality of life in patients with knee osteoarthritis Effects of Proprioceptive neuromuscular facilitation stretching vs joint mobilization for improving joint mobility and quality of life in patients with knee osteoarthritis. A randomize controlled trail 2025-03-31 anticipated 48 Complete https://irct.ir/trial/82547 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Participants will be randomly assigned to either the PNF Stretching (Group A) or Joint Mobilization (Group B) using the sealed envelope method to ensure unbiased allocation. Each eligible participant will draw a sealed envelope containing their group assignment. An independent researcher will oversee the randomization process, while the outcome assessor will remain blinded to group allocation. This method minimizes selection bias and ensures equal distribution of participants across both intervention groups, Blinding description: The outcome assessor will be **blinded** to group allocation to minimize bias in data collection and analysis. They will not be informed of participants’ assigned interventions and will only assess outcomes based on pre- and post-intervention measurements. This ensures objective evaluation of joint mobility and quality of life improvements. N/A Knee osteoarthritis. Intervention 1: Intervention group: Participants in the experimental group will undergo Proprioceptive Neuromuscular Facilitation (PNF) stretching focusing on the knee flexors and extensors. The intervention will follow a hold-relax technique, where targeted muscles will be actively contracted for 5–10 seconds, followed by a passive stretch. The intensity of stretching will gradually increase over four weeks, with longer hold durations and integration with functional movements such as sit-to-stand and step-ups. Sessions will be conducted three times per week for four weeks, with each session lasting 30–45 minutes. Both interventions will be preceded by a 5–10 minute warm-up and followed by a cool-down period to enhance treatment effectiveness and prevent injury. Intervention 2: Control group: Participants in the control group will receive joint mobilization therapy using Maitland mobilization techniques (Grade III-IV). This intervention includes anterior-posterior (AP) glides and patellar mobilization, aimed at reducing joint stiffness, improving synovial fluid movement, and enhancing knee joint mobility. The sessions will be conducted three times per week for four weeks, with each session lasting 30–45 minutes. Mobilization intensity will progress over time, incorporating weight-bearing joint mobilization and sustained holds in later weeks. Yes - There is a plan to make this available What will be shared: The shared data will be shared with the title "Effects of Proprioceptive neuromuscular facilitation stretching vs. Joint Mobilization for Improving Joint Mobility and Quality of Life in Patients with Knee Osteoarthritis: A Randomized Controlled Trial" which will include only primary outcome data i.e. range of motion for all the participants included in the study and completed the program. When: The data will be made available six months after the publication of study results and will remain accessible for a period of five years. To whom: Deidentified data will be available to researchers affiliated with academic institutions, healthcare organizations, and policymakers conducting relevant research. Industry professionals may request access with justification. Conditions: Access will be granted for scientific research, systematic reviews, and meta-analyses related to physiotherapy, osteoarthritis management, and rehabilitation. All requests will be reviewed by an independent data-sharing committee, ensuring appropriate use aligned with ethical guidelines. Where to obtain: Requests for access should be submitted via email to the principal investigator or through the institutional research office at Khyber Medical University (KMU), Institute of Physical Medicine & Rehabilitation (IPM&R). ipmr@kmu.edu.pk How to obtain: Interested researchers must submit a formal data access request, including their research objectives, ethical approval (if applicable), and data security measures. The review process may take 4–6 weeks, and approved applicants must sign a data-sharing agreement ensuring compliance with confidentiality and ethical standards. Comments: All shared data will comply with ethical, legal, and institutional guidelines to protect participant confidentiality. Any modifications to the data-sharing plan will be communicated through relevant academic channels.
public Sarmad Khattak
House No. 245 Street 7 Sector N 2 Phase 4 Hayatabad Peshawar
Peshawar Pakistan 25000 +92 91 5838666 sarmadkhattak007@gmail.com Rehman Medical Institute, Peshawar scientific Sarmad Khattak
House No. 245 Street 7 Sector N 2 Phase 4 Hayatabad Peshawar
Peshawar Pakistan 25000 +92 91 5838666 sarmadkhattak007@gmail.com Rehman Medical Institute, Peshawar Pakistan Individuals aged between 40 to 75 years diagnosed with knee osteoarthritis based on clinical and radiographic criteria Patients experiencing moderate to severe knee pain with functional limitations for at least six months. Participants with a Kellgren-Lawrence grade II–III classification of knee OA. Individuals who have not received intra-articular steroid injections or undergone knee surgery in the past six months. Patients who are willing to participate in the study and provide informed consent. 40 years 75 years Both OA patients who have received intra articular injections. Those with neurological disorders affecting lower limb function. Participants currently undergoing any other physiotherapy interventions targeting knee OA. Patients with severe knee deformities (varus/valgus) impacting normal movement mechanics. Individuals with a history of recent fractures, infections, or malignancy involving the knee joint. M17.1 Unilateral primary osteoarthritis of knee Rehabilitation Rehabilitation Intervention group: Participants in the experimental group will undergo Proprioceptive Neuromuscular Facilitation (PNF) stretching focusing on the knee flexors and extensors. The intervention will follow a hold-relax technique, where targeted muscles will be actively contracted for 5–10 seconds, followed by a passive stretch. The intensity of stretching will gradually increase over four weeks, with longer hold durations and integration with functional movements such as sit-to-stand and step-ups. Sessions will be conducted three times per week for four weeks, with each session lasting 30–45 minutes. Both interventions will be preceded by a 5–10 minute warm-up and followed by a cool-down period to enhance treatment effectiveness and prevent injury Control group: Participants in the control group will receive joint mobilization therapy using Maitland mobilization techniques (Grade III-IV). This intervention includes anterior-posterior (AP) glides and patellar mobilization, aimed at reducing joint stiffness, improving synovial fluid movement, and enhancing knee joint mobility. The sessions will be conducted three times per week for four weeks, with each session lasting 30–45 minutes. Mobilization intensity will progress over time, incorporating weight-bearing joint mobilization and sustained holds in later weeks. The primary outcome variables are joint mobility in patients with knee osteoarthritis. Timepoint: Assessments will be conducted at baseline (pre-intervention) and after four weeks (post-intervention) following the final treatment session. The outcome assessor, who is blinded to group allocation, will perform all measurements to ensure objectivity. Method of measurement: Joint mobility will be measured using a goniometer to assess knee range of motion (ROM). Khyber Medical University, Peshawar Approved 2025-03-19 KMU AS&RB 5-B/2 Shaukat Khanum Rd, Phase 5 Hayatabad, Peshawar, Khyber Pakhtunkhwa Peshawar Khyber Pakhtunkhwa Pakistan