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IRCT20241011063326N1 IRCT 2024-10-31 Mashhad University of Medical Sciences The Effect of Helicobacter Pylori Eradication on Migraine The effect of Helicobacter Pylori eradication on reducing the frequency, intensity and duration of headache attacks in migraine patients without aura 2024-11-05 anticipated 35 Complete https://irct.ir/trial/79512 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Supportive. 2 migraine. Intervention group: Helicobacter Pylori eradication regimen (3-drug regimen) with amoxicillin 1000 mg every 12 hours, clarithromycin 500 mg every 12 hours, and omeprazole 20 mg every 12 hours for 2 weeks will be given to all patients.. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information
public Hossein Alimardani
No.15 , Majd 10 Ave., Majd Blvd., Mashhad Town
Mashhad Iran (Islamic Republic of) 9184877370 +98 51 3727 7347 alimardanih4001@mums.ac.ir Mashhad University of Medical Sciences scientific Mitra Ahadi
Unit 404 , Faraz Doctors Building , Koohsangi 9 Ave , Mashhad Town
Mashhad Iran (Islamic Republic of) 9184877370 +98 51 3840 2463 ahadim@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) Migraine without aura according to IHS diagnostic criteria Helicobacter Pylori fecal antigen positive test Lack of control of migraine attacks despite the classic treatment of migraine (the MIDAS score is mostly equal to 6, which is performed by a neurologist) 16 years no limit Both Inability to cooperate Consumption of alcohol, smoking and contraceptive drugs Pregnancy G43 Migraine Treatment - Drugs Intervention group: Helicobacter Pylori eradication regimen (3-drug regimen) with amoxicillin 1000 mg every 12 hours, clarithromycin 500 mg every 12 hours, and omeprazole 20 mg every 12 hours for 2 weeks will be given to all patients. Severity score of migraine attacks in MIDAS questionnaire. Timepoint: The beginning of the study (before the start of the intervention), 3 months after completing the Helicobacter Pylori eradication regimen. Method of measurement: Migraine disability assessment questionnaire. The prevalence of Helicobacter Pylori in patients with migraine without aura. Timepoint: The beginning of the study (before the start of the intervention). Method of measurement: Helicobacter Pylori fecal antigen test. Eradication rate of Helicobacter Pylori in patients with migraine without aura after completion of treatment. Timepoint: 4 weeks after the completion of the Helicobacter Pylori eradication regimen. Method of measurement: Helicobacter Pylori fecal antigen test. Mashhad University of Medical Sciences Approved 2024-03-03 Ethics committee of Mashhad University of Medical Sciences No.15 , Majd 10 Ave., Majd Blvd., Mashhad Town Mashhad Razavi Khorasan Iran (Islamic Republic of)