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IRCT20241004063256N1 IRCT 2024-11-24 The University of Sistan and Baluchistan Investigating the effect of resistance training with and without blood flow restriction in type 2 diabetes The effect of resistance training with and without blood flow restriction on the serum levels of sirtuin1 and nitric oxide in patients with type2 diabetes 2024-12-05 anticipated 45 Complete https://irct.ir/trial/79384 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: The number of 45 diabetic patients eligible to participate in the study by non-probability sampling method (easy and accessible) and based on the purpose of selection and randomly divided into three equal groups: resistance training with blood flow restriction, resistance training without blood flow restriction and control will be divided. A table of random numbers will be used for randomization. N/A Type 2 diabetes mellitus. Intervention 1: Intervention group: resistance exercise group with blood flow restriction; This group will perform the exercises in four sets with 15, 15, 15, 30 repetitions and 20% 1RM intensity. Limitation of blood flow in the proximal part of the thigh and arm with the limiting cuff is continuously applied and during the rest between the sets, the blood flow limitation with the cuff will be removed. Intervention 2: Intervention group: resistance training group without blood flow restriction; This group will perform the exercises in four sets with 8-12 repetitions and an intensity of 80% of 1RM. Intervention 3: Control group: This group will not receive any medicine or sports intervention and will continue their normal life. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Its release schedule is not yet known
public Mahdiyeh Fatehi
Imam Khomeini St.
Zahedan Iran (Islamic Republic of) 9818614451 +98 33518210 mahdieh_fatehi@pgs.usb.ac.ir University of Sistan and Baluchistan scientific Dr. Shila Nayebifar
Daneshgah blvd.
Zahedan Iran (Islamic Republic of) 9816745845 +98 31136766 shila_nayebifar@ped.usb.ac.ir University of Sistan and Baluchistan Iran (Islamic Republic of) Age 40 to 60 years History of type 2 diabetes for more than one yaer Not consuming insulin No history of sports activity in the past year 40 years 60 years Male Having heart disease and high blood pressure Smoking Not participating regularly in training session E11 Type 2 diabetes mellitus Prevention Prevention Prevention Intervention group: resistance exercise group with blood flow restriction; This group will perform the exercises in four sets with 15, 15, 15, 30 repetitions and 20% 1RM intensity. Limitation of blood flow in the proximal part of the thigh and arm with the limiting cuff is continuously applied and during the rest between the sets, the blood flow limitation with the cuff will be removed. Intervention group: resistance training group without blood flow restriction; This group will perform the exercises in four sets with 8-12 repetitions and an intensity of 80% of 1RM Control group: This group will not receive any medicine or sports intervention and will continue their normal life. Serum level of sirtuin 1. Timepoint: Before the start of the intervention/16 weeks after the start of the intervention. Method of measurement: Measurement of sirtuin 1 concentration by ELISA method. Serum nitric oxide levels. Timepoint: Before the start of the intervention/16 weeks after the start of the intervention. Method of measurement: Using the ELISA method. Blood pressure measurement. Timepoint: before and after each training session regularly during 16 weeks of intervention. Method of measurement: Using a digital sphygmomanometer. The University of Sistan and Baluchistan Approved 2023-11-14 Group work/ Ethics committee in research of University of Sistan and Baluchistan Daneshgah blvd. Zahedan Sistan-va-Balouchestan Iran (Islamic Republic of)