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IRCT20240930063211N1 IRCT 2024-10-24 Ahvaz University of Medical Sciences Investigating the effect of magnesium sulfate on the control of acute migraine attacks Investigating the effect of magnesium sulfate along with a 3-drug regimen (keturolac, plazil and dexamethasone) on the control of acute migraine attacks . 2024-09-29 anticipated 124 Complete https://irct.ir/trial/79262 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: In this study, in order to assign patients to 2 intervention and control groups, the block randomization method is used (the size of each block is 4 patients, the total blocks are 31). In order to generate a random sequence, Epi info software is used. In this study, the hidden direction Sequencing is done using sealed envelopes and allocations are kept hidden until the last moment, Blinding description: Due to the double-blindness of the study, throughout the study, the patients, doctors, and nurses who administered the drugs were unaware of all the steps of the research, and the preparation and injection of the drugs was done by two nurses or residents, so that the person preparing the drug was different from the receiving patient. The drug and the injecting nurse were unaware of the type of drug. All drug injection syringes are uniform and randomization and data recording was done by one person (emergency medicine assistant). 2-3 Migraine. Intervention 1: Intervention group: 3-drug regimen plus magnesium sulfate (30 mg of ketorolac, 10 mg of plazil and 8 mg of Dexamethasone plus 2 grams of magnesium sulfate 50% in a volume of 100 cc. Intervention 2: Control group: 3-drug regimen (30 mg of ketorolac, 10 mg of Plazil and 8 mg of dexamethasone. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no further information
public Ali Wafaq Nematullahi
Kianpars ,Ahvaz
Ahwaz Iran (Islamic Republic of) ۶۱۹۳۶۷۳۱۶۶ 0613394810 vefagh.a@ajums.ac.ir Ahvaz University of Medical Sciences scientific Ali Wafaq Nematullahi
Kianpars,Ahwaz
Ahwaz Iran (Islamic Republic of) ۶۱۹۳۶۷۳۱۶۶ 0613394810 vefagh.a@ajums.ac.ir Ahvaz University of Medical Sciences Iran (Islamic Republic of) Patients with migraine headaches have a pain score greater than 5 (based on visual analog scale (VAS)). The age of the patients should be between 18 and 60 years Consciousness level equal to 15 18 years 60 years Both Pregnancy or suspected pregnancy History of alcoholism, sensitivity to morphine or painkillers History of mental illness and depression and recent use of sedatives or antipsychotics and use of calcium channel blockers History of cardiac, kidney, liver and metabolic disease The patient's unwillingness to participate in the study G43.0 Migraine without aura Treatment - Drugs Treatment - Drugs Intervention group: 3-drug regimen plus magnesium sulfate (30 mg of ketorolac, 10 mg of plazil and 8 mg of Dexamethasone plus 2 grams of magnesium sulfate 50% in a volume of 100 cc Control group: 3-drug regimen (30 mg of ketorolac, 10 mg of Plazil and 8 mg of dexamethasone Patients with a history of migraine headaches whose pain score was greater than 5 based on the analog visual scale. Timepoint: On arrival, 1 hour and 2 hours after administration of the drug. Method of measurement: visual analog scale (VAS). Measuring the scale of Pain Healing in Patients. Timepoint: On arrival, 1 hour and 2 hours after administration of the drug. Method of measurement: Hemodynamic disorder is assessed by measuring systolic and diastolic blood pressure using a digital sphygmomanometer, and heart rate using a pulse oximeter or heart monitoring. Ahvaz University of Medical Sciences Approved 2024-09-29 Ethics committee of Ahvaz University of Medical Sciences Informatics Department,First Floor,Research and Technology Vice-Chancellor,Ahvaz University City Ahvaz Khouzestan Iran (Islamic Republic of)