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IRCT20240926063171N1 IRCT 2024-11-21 Tehran University of Medical Sciences Comparison of different concentrations of mesotherapy with tranexamic acid in patients with the complaint of Darkness around the eyes Comparison of different concentrations of mesotherapy with tranexamic acid in patients with the complaint of Darkness around the eyes 2024-10-22 anticipated 23 Complete https://irct.ir/trial/79251 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients were randomly assigned to groups of 100 and 10 trengsamic acid concentrations for the eyelid of each eye through a double-blind block randomization method. Thus, each person was considered as a block. Double blocks are made in such a way that the combination of AB Treatment A is injected into the right eyelid of the person and treatment B is injected into the left eyelid. In order to prepare a random list, it is used in such a way that a random number is selected at each step, if the selected number is between 0 and 4, it is AB combination and if it is between 5 and 9 BA composition is considered.Therefore, we will repeat this process many times until eligible patients enter the study according to the output of the Random Allocation software, which is reported as follows. AB code: 0001 means the left and right eyelids of the first person treated with A and the left eye lid of the first person treated. B should be injected. In addition, the BA code is 0002, which means that the right eyelid of the second patient should be injected with treatment B and the left eyelid of the second patient should be injected with treatment A, Blinding description: Participants The doctor who performs the injection procedure Nurses and health personnel Referrals of participants Data security and monitoring committee Those who prepare the draft of the article be blinded. 3 Darkness around the eyes. Intervention 1: Intervention group:in Intervention group one, patients with dark circles around the eyes, the combination of the same AB means that the lower right eyelid A and the lower left eyelid B are injected. Intervention 2: Intervention group: In intervention group 2, patients with dark circles around the eyesThe composition of BA concentration means that the lower right eyelid is injected with concentration B, the lower left eyelid with concentration A. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is I need to study more
public Nasim mazloomi tootoonchi
Razi Skin Hospital, Vahdat Islamic St., Tehran
Tehran Iran (Islamic Republic of) 1193640002 +98 21 5563 4461 ansarims@sina.tums.ac.ir Tehran University of Medical Sciences scientific Nasim mazloomi tootoonchi
Razi Skin Hospital, Vahdat Islamic St., Tehran
Tehran Iran (Islamic Republic of) 1193640002 +98 21 5563 4461 ansarims@sina.tums.ac.ir Tehran University of Medical Sciences Iran (Islamic Republic of) Not in the context of atopic dermatitis Has not been treated with PRP and mesotherapy in the last 6 months The form has been taken knowingly Darkness around the eyes has been confirmed by a dermatologist 18 years 50 years Both pregnancy breastfeeding Receiving anticoagulant medication Treatment - Drugs Treatment - Drugs Intervention group:in Intervention group one, patients with dark circles around the eyes, the combination of the same AB means that the lower right eyelid A and the lower left eyelid B are injected Intervention group: In intervention group 2, patients with dark circles around the eyesThe composition of BA concentration means that the lower right eyelid is injected with concentration B, the lower left eyelid with concentration A. Darkness and hyperpigmentation around the eyes. Timepoint: before the start of treatment, three weeks after the start of therapy and the third time 8 to 12 weeks after the start of treatment. Method of measurement: During three rounds, photos are taken using an 8 megapixel digital camera. Tehran University of Medical Sciences Approved 2023-09-12 Ethics committee of Tehran University of Medical Sciences Ghods St., Porsina St., Faculty of Medical Sciences Tehran Tehran Iran (Islamic Republic of)