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IRCT20140415017288N12 IRCT 2024-09-07 Islamic Azad University Effect of Exercise and Cinnamon on Diabetic Women Effect of Different Intensities of Aerobic Exercise Combined with Resistance Exercise and Cinnamon Consumption on Meteorin-like protein (Metrnl), Irisin and Inflammatory Factors in Diabetic Women 2024-08-15 anticipated 54 Complete https://irct.ir/trial/77850 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Used, Assignment: Parallel, Purpose: Health service research, Randomization description: In this research, subjects are selected Simple randomization by random allocation rule. After determining the sample size, they will be equally divided into 6 groups (Control, moderate-intensity aerobic training + resistance training, high-intensity aerobic training + resistance training, cinnamon, moderate-intensity aerobic training + resistance training + cinnamon and high-intensity aerobic training + resistance training + cinnamon). Using the lottery method, the names of the subjects are written on separate papers and placed in a container, then the names of the subjects are randomly taken out and placed in the intervention groups or placebo, respectively, Blinding description: Each capsule will contain 500 mg of cinnamon powder, and each subject will receive one capsule in the morning immediately after breakfast and one capsule after lunch, and the control and exercise groups will receive the same amount of placebo. Starch is used as a placebo. 3 Type 2 Diabetes. Intervention 1: Intervention group 1: We will consider this group as the control group. Intervention 2: Intervention group 2: Moderate-intensity aerobic training+resistance training group (In this group, for 8 weeks, five session/weeks, the training start with 10 minutes of warm-up. Aerobic exercise with an intensity of 50% VO2max is performed along with TRX exercise. The total energy of exercise is about 400 kcal). Intervention 3: Intervention group 3: High-intensity aerobic training+resistance training group (In this group, for 8 weeks, five session/weeks, the training start with 10 minutes of warm-up. Aerobic exercise with an intensity of 80% VO2max is performed along with TRX exercise. The total energy of exercise is about 400 kcal). Intervention 4: Intervention group 4: Cinnamon supplementation group (in this group eat 1000 mg of cinnamon supplementation for eight weeks Twice a day after breakfast and lunch). Intervention 5: Intervention group 5: Moderate-intensity aerobic training+resistance training+cinnamon group (In this group the Simultaneous intervention, moderate-intensity aerobic training+resistance training+cinnamon, will treat with the same protocol that describe at the previous part). Intervention 6: Intervention group 6: High-intensity aerobic training+resistance training+cinnamon group (In this group the Simultaneous intervention, high-intensity aerobic training+resistance training+cinnamon, will treat with the same protocol that describe at the previous part). Yes - There is a plan to make this available What will be shared: The report is submitted to the research department of the university. Also published as a paper. When: Since 2025 To whom: All researchers Conditions: Citing references Where to obtain: Scientific bases and Ayatollah Amoli Branch, Islamic Azad University, amol, Iran How to obtain: Maximum one week Comments:
public Ahmad Abdi
Ayatollah Amoli Branch, Islamic Azad University
Amol Iran (Islamic Republic of) 461671618 +98 11 4321 7126 A.abdi@iauamol.ac.ir Islamic Azad University scientific Alireza Barari
Ayatollah Amoli Branch, Islamic Azad University
Amol Iran (Islamic Republic of) 4616716187 +98 11 4321 7126 Alireza54.barari@gmail.com Islamic Azad University Iran (Islamic Republic of) Type 2 diabetes (people with a history of more than twice the fasting glucose above 126 mg / dL with HbA1c above 6.5% and under the supervision of a physician at the time of the study). Subjects were asked to complete a questionnaire of readiness to start sports. Lack of cardiovascular, Lack of musculoskeletal, Lack of metabolic diseases limited exercise, lack of high blood pressure, lack of a history of regular exercise during the past six months, lack of insulin. Age range in the range of 35-50 years. Inactive lifestyle (exercise less than 1 hour per week). Consent to participate in the study. 35 years 50 years Female Use of drugs that lower blood pressure and blood lipids Exclusion criteria included a history of serious diabetic complications (such as proliferative diabetic retinopathy, stage 3 or subsequent overt nephropathy, diabetic ketoacidosis or severe diabetic neuropathy). fasting glucose above 270 mg / dL malaise Hereditary absorption of glucose and galactose or renal glycosuria. Detection of other underlying diseases during the implementation of the protocol, such as cardiopulmonary problems and musculoskeletal disorders during exercise that prevent the performance of the activity. E11 Type 2 diabetes mellitus Placebo Treatment - Other Treatment - Other Treatment - Other Treatment - Other Treatment - Other Intervention group 1: We will consider this group as the control group. Intervention group 2: Moderate-intensity aerobic training+resistance training group (In this group, for 8 weeks, five session/weeks, the training start with 10 minutes of warm-up. Aerobic exercise with an intensity of 50% VO2max is performed along with TRX exercise. The total energy of exercise is about 400 kcal). Intervention group 3: High-intensity aerobic training+resistance training group (In this group, for 8 weeks, five session/weeks, the training start with 10 minutes of warm-up. Aerobic exercise with an intensity of 80% VO2max is performed along with TRX exercise. The total energy of exercise is about 400 kcal). Intervention group 4: Cinnamon supplementation group (in this group eat 1000 mg of cinnamon supplementation for eight weeks Twice a day after breakfast and lunch) Intervention group 5: Moderate-intensity aerobic training+resistance training+cinnamon group (In this group the Simultaneous intervention, moderate-intensity aerobic training+resistance training+cinnamon, will treat with the same protocol that describe at the previous part). Intervention group 6: High-intensity aerobic training+resistance training+cinnamon group (In this group the Simultaneous intervention, high-intensity aerobic training+resistance training+cinnamon, will treat with the same protocol that describe at the previous part). Effect of training and cinnamon supplementation on Metrnl. Timepoint: Before and after the protocol. Method of measurement: Biochemical and laboratory methods. Effect of training and cinnamon supplementation on Irisin. Timepoint: Before and after the protocol. Method of measurement: Biochemical and laboratory methods. Effect of training and cinnamon supplementation on PGC-1α. Timepoint: Before and after the protocol. Method of measurement: Biochemical and laboratory methods. Effect of training and cinnamon supplementation on TNF-α. Timepoint: Before and after the protocol. Method of measurement: Biochemical and laboratory methods. Effect of training and cinnamon supplementation on TGF-β. Timepoint: Before and after the protocol. Method of measurement: Biochemical and laboratory methods. Effect of training and cinnamon supplementation on IL-2. Timepoint: Before and after the protocol. Method of measurement: Biochemical and laboratory methods. Effect of training and cinnamon supplementation on IL-10. Timepoint: Before and after the protocol. Method of measurement: Biochemical and laboratory methods. Islamic Azad University Approved 2024-07-12 Ethics Committee of Islamic Azad University - Ayatollah Amoli Branch Islamic Azad University, Ayatollah Amoli branch, Komdareh village, km 5 of the old Amol-Babol road. Amol Mazandaran Iran (Islamic Republic of)